5VDK Chain A
Wee1-like protein kinase 2 (WEE2)
Active — 94.7%DFG-inαC-inType1 · 8X7
Resolution
2.7 Å
R-value
0.228
Predicted activity confidence94.7%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
MASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKVMYKIGDLGHATSINKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVL
UniProt reference sequence
FLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVL
Aligned reference sequence
FLEV----------------EKIGVGE----------------FGTVYKCIK--RL------------------------------------DGCVYAIKRSM--KTFTELSN--------------------------ENSALHEVYAHAVL--G-----------------------HHPHVVRYYSSWAEDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMIIQNEYCNG--------------GSLQAAISE--NTKSGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFEEPKLKDILLQISLGLNYIHNS---------------------------------------------SMVHLDI-----KPSNIFICH--KMQSESSGVIEEVENEADWFLSA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVMYKIGDLGHATSINKP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVEEGDSRFLANEILQE--D-----------------------------YRHL-PKADIFALGLTIAVAAGA-------------------------ESL---------------------------------------------PTNGAAWHHIRKG--NFPDVPQELS-----------------------------------------------------------------------------------------------------ESFSSLLKNMIQPDAEQRPS--------------AAALARNTVL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FLEV----------------EKIGVGE----------------FGTVYKCIK--RL------------------------------------DGCVYAIKRSM--KTFTELSN--------------------------ENSALHEVYAHAVL--G-----------------------HHPHVVRYYSSWAEDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMIIQNEYCNG--------------GSLQAAISE--NTKSGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFEEPKLKDILLQISLGLNYIHNS---------------------------------------------SMVHLDI-----KPSNIFICH--K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VMYKIGDLGHATSINKP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVEEGDSRFLANEILQE--D-----------------------------YRHL-PKADIFALGLTIAVAAGA-------------------------ESL---------------------------------------------PTNGAAWHHIRKG--NFPDVPQELS-----------------------------------------------------------------------------------------------------ESFSSLLKNMIQPDAEQRPS--------------AAALARNTVL
Activation segment
DLGHATSINKP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVEEGDSRFLANE
Binding pocket
EKIGVGEFGTVYKYAIKRSSALHEVYAHAVLGPHVVRYYSSIIQNEYCNGGSLQAAISEYIHNSSMVHLDIKPSNIFIIGDLGHA
Ligand info
Orthosteric ligand
8X7
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5VDK, Chain A