5V5N Chain A
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)
Inactive — 0.0%DFG-inαC-inType1 · EDH
Resolution
2.01 Å
R-value
0.194
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SLHMIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQHSLPPGEDGRVEPYVDFAEFYRLWSVDHG
UniProt reference sequence
IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTH
Aligned reference sequence
IEVE----------------EVVGRGA----------------FGVVCKAKW----------------------------------------RAKDVAIKQIE--SESE------------------------------RKAFIVELRQLSRV--------------------------NHPNIVKLYGACLN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVCLVMEYAEG--------------GSLYNVLHG--AEPLP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYTAAHAMSWCLQCSQGVAYLHSM--QPK----------------------------------------ALIHRDL-----KPPNLLLVA--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVLKICDFGTACDIQTHM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNNKGSAAWMAPEVFEG--------------------------------SNYS-EKCDVFSWGIILWEVITR-----------------RKPFDE--IG----------------------------------------------GPAFRIMWAVHNG--TRPPLIKNLP-----------------------------------------------------------------------------------------------------KPIESLMTRCWSKDPSQRPS--------------MEEIVKIMTH
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IEVE----------------EVVGRGA----------------FGVVCKAKW----------------------------------------RAKDVAIKQIE--SESE------------------------------RKAFIVELRQLSRV--------------------------NHPNIVKLYGACLN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVCLVMEYAEG--------------GSLYNVLHG--AEPLP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYTAAHAMSWCLQCSQGVAYLHSM--QPK----------------------------------------ALIHRDL-----KPPNLLLVA--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVLKICDFGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSAAWMAPEVFEG--------------------------------SNYS-EKCDVFSWGIILWEVITR-----------------RKPFDE--IG----------------------------------------------GPAFRIMWAVHNG--TRPPLIKNLP-----------------------------------------------------------------------------------------------------KPIESLMTRCWSKDPSQRPS--------------MEEIVKIMTH
Activation segment
DFGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSAAWMAPE
Binding pocket
EVVGRGAFGVVCKVAIKQIAFIVELRQLSRVNPNIVKLYGACLVMEYAEGGSLYNVLHGSMQPKALIHRDLKPPNLLLICDFGT_
Ligand info
Orthosteric ligand
EDH
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5V5N, Chain A