5UOR Chain B
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
Active — 95.7%DFG-inαC-inType1 · 8GV
Resolution
2.75 Å
R-value
0.205
Predicted activity confidence95.7%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLTFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK
UniProt reference sequence
YDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFL
Aligned reference sequence
YDYE--YDENGDR-------VVLGKGT----------------YGIVYAGRD--LS------------------------------------NQVRIAIKEIP--ERDSRY----------------------------SQPLHEEIALHKHL--------------------------KHKNIVQYLGSFSENG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FIKIFMEQVPG--------------GSLSALLRS--KWGPL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDNEQTIGFYTKQILEGLKYLHDN---------------------------------------------QIVHRDI-----KGDNVLINT--Y-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGVLKISDFGTSKRLAGINPC--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETFTGTLQYMAPEIIDK--GP----------------------------RGYG-KAADIWSLGCTIIEMATG-----------------KPPFYE--L-----------------------------------------------GEPQAAMFKVGMF--KVHPEIPESMS----------------------------------------------------------------------------------------------------AEAKAFILKCFEPDPDKRAC--------------ANDLLVDEFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YDYE--YDENGDR-------VVLGKGT----------------YGIVYAGRD--LS------------------------------------NQVRIAIKEIP--ERDSRY----------------------------SQPLHEEIALHKHL--------------------------KHKNIVQYLGSFSENG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FIKIFMEQVPG--------------GSLSALLRS--KWGPL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDNEQTIGFYTKQILEGLKYLHDN---------------------------------------------QIVHRDI-----KGDNVLINT--Y-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGVLKISDFGTSKRL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTGTLQYMAPEIIDK--GP----------------------------RGYG-KAADIWSLGCTIIEMATG-----------------KPPFYE--L-----------------------------------------------GEPQAAMFKVGMF--KVHPEIPESMS----------------------------------------------------------------------------------------------------AEAKAFILKCFEPDPDKRAC--------------ANDLLVDEFL
Activation segment
DFGTSKRL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTGTLQYMAPE
Binding pocket
VVLGKGTYGIVYAIAIKEIPLHEEIALHKHLKKNIVQYLGSKIFMEQVPGGSLSALLRSYLHDNQIVHRDIKGDNVLIISDFGTS
Ligand info
Orthosteric ligand
8GV
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5UOR, Chain B