5U6B Chain C
Tyrosine-protein kinase receptor UFO (AXL)
Inactive — 0.0%DFG-inαC-outType1 · 7YS
Resolution
2.84 Å
R-value
0.212
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPA
UniProt reference sequence
VALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLEN
Aligned reference sequence
VALG----------------KTLGEGE----------------FGAVMEGQL--NQDD----------------------------------SILKVAVKTMK--IAICTRSE--------------------------LEDFLSEAVCMKEF--------------------------DHPNVMRLIGVCFQGS--ERESFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APVVILPFMKH--------------GDLHSFLLY--SRLGDQPV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLPTQMLVKFMADIASGMEYLSTK---------------------------------------------RFIHRDL-----AARNCMLNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMSVCVADFGLSKKIYNGDYY--RQG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIAKMPVKWIAIESLAD--------------------------------RVYT-SKSDVWSFGVTMWEIATR--G--------------QTPYPG--------------------------------------------------VENSEIYDYLRQG--NRLKQPADCL-----------------------------------------------------------------------------------------------------DGLYALMSRCWELNPQDRPS--------------FTELREDLEN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VALG----------------KTLGEGE----------------FGAVMEGQL--NQDD----------------------------------SILKVAVKTMK--IAICTRSE--------------------------LEDFLSEAVCMKEF--------------------------DHPNVMRLIGVCFQ---------P------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APVVILPFMKH--------------GDLHSFLLY--SRLGDQPV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLPTQMLVKFMADIASGMEYLSTK---------------------------------------------RFIHRDL-----AARNCMLNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMSVCVADFGLSK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWIAIESLAD--------------------------------RVYT-SKSDVWSFGVTMWEIATR--G--------------QTPYPG--------------------------------------------------VENSEIYDYLRQG--NRLKQPADCL-----------------------------------------------------------------------------------------------------DGLYALMSRCWELNPQDRPS--------------FTELREDLEN
Activation segment
DFGLSK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWIAIE
Binding pocket
KTLGEGEFGAVMEVAVKTMDFLSEAVCMKEFDPNVMRLIGVVVILPFMKHGDLHSFLLYYLSTKRFIHRDLAARNCMLVADFGLS
Ligand info
Orthosteric ligand
7YS
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5U6B, Chain C