5TC0 Chain B
Tyrosine-protein kinase Mer (MERTK)
Inactive — 0.1%DFG-inαC-out
Resolution
2.24 Å
R-value
0.229
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues9
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
EDVVIDRNLLILGKILSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVMRLLGVCIKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL
UniProt reference sequence
LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEK
Aligned reference sequence
LILG----------------KILGEGE----------------FGSVMEGNL--KQEDG---------------------------------TSLKVAVKTMK--LDNSSQRE--------------------------IEEFLSEAACMKDF--------------------------SHPNVIRLLGVCIEMS--SQGIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPMVILPFMKY--------------GDLHTYLLY--SRLETGPK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIPLQTLLKFMVDIALGMEYLSNR---------------------------------------------NFLHRDL-----AARNCMLRD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADFGLSKKIYSGDYY--RQG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIAKMPVKWIAIESLAD--------------------------------RVYT-SKSDVWAFGVTMWEIATR--G--------------MTPYPG--------------------------------------------------VQNHEMYDYLLHG--HRLKQPEDCL-----------------------------------------------------------------------------------------------------DELYEIMYSCWRTDPLDRPT--------------FSVLRLQLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LILG----------------KIL----------------------SVMEGNL--KQEDG---------------------------------TSLKVAVKTMK--LDNSSQRE--------------------------IEEFLSEAACMKDF--------------------------SHPNVMRLLGVCI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPMVILPFMKY--------------GDLHTYLLY--SRLETGPK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIPLQTLLKFMVDIALGMEYLSNR---------------------------------------------NFLHRDL-----AARNCMLRD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWIAIESLAD--------------------------------RVYT-SKSDVWAFGVTMWEIATR--G--------------MTPYPG--------------------------------------------------VQNHEMYDYLLHG--HRLKQPEDCL-----------------------------------------------------------------------------------------------------DELYEIMYSCWRTDPLDRPT--------------FSVLRLQLEK
Activation segment
DF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWIAIE
Binding pocket
KIL______SVMEVAVKTMEFLSEAACMKDFSPNVMRLLGVMVILPFMKYGDLHTYLLYYLSNRNFLHRDLAARNCMLVADF___
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5TC0, Chain B