5TC0 Chain A
Tyrosine-protein kinase Mer (MERTK)
Inactive — 0.0%DFG-inαC-outType1 · 79Y
Resolution
2.24 Å
R-value
0.229
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues12
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
EDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFMPVKWIAIETSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL
UniProt reference sequence
LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEK
Aligned reference sequence
LILG----------------KILGEGE----------------FGSVMEGNL--KQEDG---------------------------------TSLKVAVKTMK--LDNSSQRE--------------------------IEEFLSEAACMKDF--------------------------SHPNVIRLLGVCIEMS--SQGIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPMVILPFMKY--------------GDLHTYLLY--SRLETGPK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIPLQTLLKFMVDIALGMEYLSNR---------------------------------------------NFLHRDL-----AARNCMLRD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADFGLSKKIYSGDYY--RQG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIAKMPVKWIAIESLAD--------------------------------RVYT-SKSDVWAFGVTMWEIATR--G--------------MTPYPG--------------------------------------------------VQNHEMYDYLLHG--HRLKQPEDCL-----------------------------------------------------------------------------------------------------DELYEIMYSCWRTDPLDRPT--------------FSVLRLQLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LILG----------------KILGEGE----------------FGSVMEGNL--KQEDG---------------------------------TSLKVAVKT------------------------------------------------MKDF--------------------------SHPNVMRLLGVCIEMS--SQGIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPMVILPFMKY--------------GDLHTYLLY--SRLETGPK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIPLQTLLKFMVDIALGMEYLSNR---------------------------------------------NFLHRDL-----AARNCMLRD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPVKWIAIE---------------------------------------T-SKSDVWAFGVTMWEIATR--G--------------MTPYPG--------------------------------------------------VQNHEMYDYLLHG--HRLKQPEDCL-----------------------------------------------------------------------------------------------------DELYEIMYSCWRTDPLDRPT--------------FSVLRLQLEK
Activation segment
DF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPVKWIAIE
Binding pocket
KILGEGEFGSVMEVAVKT_________MKDFSPNVMRLLGVMVILPFMKYGDLHTYLLYYLSNRNFLHRDLAARNCMLVADF___
Ligand info
Orthosteric ligand
79Y
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5TC0, Chain A