5S7O Chain A
Activin receptor type-1 (ACVR1)
Active — 90.1%DFG-inαC-in
Resolution
1.43 Å
R-value
0.165
Predicted activity confidence90.1%
Structure info
Alternate conformationC
Missing atoms19
Missing residues4
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
QRTVARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID
UniProt reference sequence
ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTK
Aligned reference sequence
ITLL----------------ECVGKGR----------------YGEVWRGSW----------------------------------------QGENVAVKIFS--SRD-------------------------------EKSWFRETELYNTV--ML----------------------RHENILGFIASDMTSR--HSST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLITHYHEM--------------GSLYDYLQL--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIE--IFGTQGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGQCCIADLGLAVMHSQSTNQ--LDVGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPEVLDE--TIQVDC------------------------FDSY-KRVDIWAFGLVLWEVARR--MVSNGIVEDY-----KPPFYD--VVPND-------------------------------------------PSFEDMRKVVCVD--QQRPNIPNRWFSDPTL-----------------------------------------------------------------------------------------------TSLAKLMKECWYQNPSARLT--------------ALRIKKTLTK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLL----------------ECVGKGR----------------YGEVWRGSW----------------------------------------QGENVAVKIFS--SRD-------------------------------EKSWFRETELYNTV--ML----------------------RHENILGFIASDMTSR--HSST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLITHYHEM--------------GSLYDYLQL--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIE--IFG-QGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGQCCIADLGLAVMHS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRVGTKRYMAPEVLDE--TIQVDC------------------------FDSY-KRVDIWAFGLVLWEVARR--MVSNGIVEDY-----KPPFYD--VVPND-------------------------------------------PSFEDMRKVVCVD--QQRPNIPNRWFSDPTL-----------------------------------------------------------------------------------------------TSLAKLMKECWYQNPSARLT--------------ALRIKKTLTK
Activation segment
DLGLAVMHS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRVGTKRYMAPE
Binding pocket
ECVGKGRYGEVWRVAVKIFSWFRETELYNTVMEN_LGFIASWLITHYHEMGSLY_YLQL_QGKPAIAHRDLKSKNILVIADLG_A
Ligand info
Orthosteric ligand
None
Allosteric ligand
LU8
Ligand typeType1,Allosteric,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5S7O, Chain A