5OKT Chain D
Casein kinase I isoform delta (CSNK1D)
Active — 100.0%DFG-inαC-inType1 · 9XK
Resolution
2.13 Å
R-value
0.194
Predicted activity confidence100.0%
Structure info
Alternate conformationB
Missing atoms7
Missing residues6
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LRVGNRYRLGRKGDIYLGTDIAAGEEVAIKLECHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
UniProt reference sequence
YRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRN
Aligned reference sequence
YRLG----------------RKIGSGS----------------FGDIYLGTD--IA------------------------------------AGEEVAIKLEC--VKTK------------------------------HPQLHIESKIYKMM--Q-----------------------GGVGIPTIRWCGAEGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVMVMELLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFSLKTVLLLADQMISRIEYIHSK---------------------------------------------NFIHRDV-----KPDNFLMGL--GKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNLVYIIDFGLAKKYRDARTH--QHIPYREN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASINTHLG--------------------------------IEQS-RRDDLESLGYVLMYFNLG-----------------SLPWQG--LKAATKR-----------------------------------------QKYERISEKKMST--PIEVLCKGYP-----------------------------------------------------------------------------------------------------SEFATYLNFCRSLRFDDKPD--------------YSYLRQLFRN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LRVG----------------NRYRLGR----------------KGDIYLGTD--IA------------------------------------AGEEVAIKLEC------------------------------------HPQLHIESKIYKMM--Q-----------------------GGVGIPTIRWCGAEGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVMVMELLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFSLKTVLLLADQMISRIEYIHSK---------------------------------------------NFIHRDV-----KPDNFLMGL--GKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNLVYIIDFGLAKKYRDARTH--QHIPYREN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASINTHLG--------------------------------IEQS-RRDDLESLGYVLMYFNLG-----------------SLPWQG--LKAATKR-----------------------------------------QKYERISEKKMST--PIEVLCKGYP-----------------------------------------------------------------------------------------------------SEFATYLNFCRSLRFDDKPD--------------YSYLRQLFRN
Activation segment
DFGLAKKYRDARTH--QHIPYREN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASIN
Binding pocket
RK______GDIYLVAIKLEQLHIESKIYKMMQVGIPTIRWCVMVMELLG_PSLEDLFNFYIHSKNFIHRDVKPDNFLMIIDFGLA
Ligand info
Orthosteric ligand
9XK
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5OKT, Chain D