5O49 Chain B
Fibroblast growth factor receptor 1 (FGFR1)
Inactive — 0.0%DFG-inαC-inType1 · 9K5
Resolution
1.91 Å
R-value
0.2
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms12
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
VSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE
UniProt reference sequence
LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
Aligned reference sequence
LVLG----------------KPLGEGC----------------FGQVVLAEA--IGLDKDKPN-----------------------------RVTKVAVKMLK--SDATEKD---------------------------LSDLISEMEMMKMI--G-----------------------KHKNIINLLGACTQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVEYASK--------------GNLREYLQA--RRPPGLEYCYNPSHNPEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLSSKDLVSCAYQVARGMEYLASK---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLARDIHHIDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPEALFD--------------------------------RIYT-HQSDVWSFGVLLWEIFTL--G--------------GSPYPG--------------------------------------------------VPVEELFKLLKEG--HRMDKPSNCT-----------------------------------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT--------------FKQLVEDLDR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------KPLGEGA----------------FGQVVLAEA--IGLD---PN-----------------------------RVTKVAVKMLK--SDATEKD---------------------------LSDLISEMEMMKMI--G-----------------------KHKNIINLLGACTQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVEYASK--------------GNLREYLQA--RRPPG------------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLSSKDLVSCAYQVARGMEYLASK---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGL-----HIDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPEALFD--------------------------------RIYT-HQSDVWSFGVLLWEIFTL--G--------------GSPYPG--------------------------------------------------VPVEELFKLLKEG--HRMDKPSNCT-----------------------------------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT--------------FKQLVEDLDR
Activation segment
DFGL-----HIDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPE
Binding pocket
KPLGEGAFGQVVLVAVKMLDLISEMEMMKMIGKNIINLLGAYVIVEYASKGNLREYLQAYLASKKCIHRDLAARNVLVIADFGL_
Ligand info
Orthosteric ligand
9K5
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5O49, Chain B