5O2B Chain B
Serine/threonine-protein kinase WNK3 (WNK3)
Inactive — 0.0%DFG-inαC-outType1 · KS1
Resolution
2.04 Å
R-value
0.201
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms20
Missing residues0
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
MKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFA
UniProt reference sequence
FLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF
Aligned reference sequence
FLKF--D-------------IELGRGA----------------FKTVYKGLD--TE------------------------------------TWVEVAWCELQ--DRKLTKAE--------------------------QQRFKEEAEMLKGL--------------------------QHPNIVRFYDSWESIL--KGKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CIVLVTELMTS--------------GTLKTYLKR--FK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VMKPKVLRSWCRQILKGLQFLHTR--TP-----------------------------------------PIIHRDL-----KCDNIFITG--P-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGSVKIGDLGLATLMRTSFA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSVIGTPEFMAPEMYE---------------------------------EHYD-ESVDVYAFGMCMLEMATS-----------------EYPYSE--C-----------------------------------------------QNAAQIYRKVTSG--IKPASFNKVTD----------------------------------------------------------------------------------------------------PEVKEIIEGCIRQNKSERLS--------------IRDLLNHAFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FLKF--D-------------IELGRGA----------------FKTVYKGLD--TE------------------------------------TWVEVAWCELQ--D---TKAE--------------------------QQRFKEEAEMLKGL--------------------------QHPNIVRFYDSWESIL--KGKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CIVLVTELMTS--------------GTLKTYLKR--FK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VMKPKVLRSWCRQILKGLQFLHTR--TP-----------------------------------------PIIHRDL-----KCDNIFITG--P-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGSVKIGDLGLATLM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPEFMAPEMYE---------------------------------EHYD-ESVDVYAFGMCMLEMATS-----------------EYPYSE--C-----------------------------------------------QNAAQIYRKVTS----KPASFNKVTD----------------------------------------------------------------------------------------------------PEVKEIIEGCIRQNKSERLS--------------IRDLLNHAFF
Activation segment
DLGLATLM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPEFMAPE
Binding pocket
IELGRGAFKTVYKVAWCELRFKEEAEMLKGLQPNIVRFYDSVLVTELMTSGTLKTYLKRHTRTPPIIHRDLKCDNIFIIGDLGLA
Ligand info
Orthosteric ligand
KS1
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5O2B, Chain B