5O1V Chain A
Serine/threonine-protein kinase WNK3 (WNK3)
Inactive — 0.3%DFG-inαC-out
Resolution
1.72 Å
R-value
0.175
Predicted activity confidence0.3%
Structure info
Alternate conformationA
Missing atoms10
Missing residues0
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
EMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLR
UniProt reference sequence
FLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF
Aligned reference sequence
FLKF--D-------------IELGRGA----------------FKTVYKGLD--TE------------------------------------TWVEVAWCELQ--DRKLTKAE--------------------------QQRFKEEAEMLKGL--------------------------QHPNIVRFYDSWESIL--KGKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CIVLVTELMTS--------------GTLKTYLKR--FK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VMKPKVLRSWCRQILKGLQFLHTR--TP-----------------------------------------PIIHRDL-----KCDNIFITG--P-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGSVKIGDLGLATLMRTSFA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSVIGTPEFMAPEMYE---------------------------------EHYD-ESVDVYAFGMCMLEMATS-----------------EYPYSE--C-----------------------------------------------QNAAQIYRKVTSG--IKPASFNKVTD----------------------------------------------------------------------------------------------------PEVKEIIEGCIRQNKSERLS--------------IRDLLNHAFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FLKF--D-------------IELGRGA----------------FKTVYKGLD--TE------------------------------------TWVEVAWCELQ--DRKLTKAE--------------------------QQRFKEEAEMLKGL--------------------------QHPNIVRFYDSWESIL--KGKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CIVLVTELMTS--------------GTLKTYLKR--FK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VMKPKVLRSWCRQILKGLQFLHTR--TP-----------------------------------------PIIHRDL-----KCDNIFITG--P-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGSVKIGDLGLATLMRT-FA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSVIGTPEFMAPEMYE---------------------------------EHYD-ESVDVYAFGMCMLEMATS-----------------EYPYSE--C-----------------------------------------------QNAAQIYRKVTSG--IKPASFNKVTD----------------------------------------------------------------------------------------------------PEVKEIIEGCIRQNKSERLS--------------IRDLLNHAFF
Activation segment
DLGLATLMRT-FA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSVIGTPEFMAPE
Binding pocket
IELGRGAFKTVYKVAWCELRFKEEAEMLKGLQPNIVRFYDSVLVTELMTSGTLKTYLKRHTRTPPIIHRDLKCDNIFIIGDLGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5O1V, Chain A