5O0Y Chain A
Serine/threonine-protein kinase tousled-like 2 (TLK2)
Active — 67.8%DFG-inαC-inATPlike · AGS
Resolution
2.86 Å
R-value
0.184
Predicted activity confidence67.8%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLP
UniProt reference sequence
YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL
Aligned reference sequence
YLLL----------------HLLGRGG----------------FSEVYKAFD--LT------------------------------------EQRYVAVKIHQ--LNKNWRDEKKENY---------------------HKHACREYRIHKEL--------------------------DHPRIVKLYDYFSLDT--D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SFCTVLEYCEG--------------NDLDFYLKQ--HK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LMSEKEARSIIMQIVNALKYLNEI--KP-----------------------------------------PIIHYDL-----KPGNILLVN--GTA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGEIKITDFGLSKIMDDDSYN--SVDGMELT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGAGTYWYLPPECFVV--GKEP--------------------------PKIS-NKVDVWSVGVIFYQCLYG-----------------RKPFGH--NQSQQDILQE---------------------------------------------NTILKA--TEVQFPPKPVVT---------------------------------------------------------------------------------------------------PEAKAFIRRCLAYRKEDRID--------------VQQLACDPYL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YLLL----------------HLLGRGG----------------FSEVYKAFD--LT------------------------------------EQRYVAVKIHQ--LNKNWRDEKKENY---------------------HKHACREYRIHKEL--------------------------DHPRIVKLYDYFSLDT--D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SFCTVLEYCEG--------------NDLDFYLKQ--HK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LMSEKEARSIIMQIVNALKYLNEI--KP-----------------------------------------PIIHYDL-----KPGNILLVN--GTA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGEIKITDFGLSKIMDDDSYN--SVDGMELT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGAGTYWYLPPECFVV--GKEP--------------------------PKIS-NKVDVWSVGVIFYQCLYG-----------------RKPFGH--NQSQQDILQE---------------------------------------------NTILKA--TEVQFPPKPVVT---------------------------------------------------------------------------------------------------PEAKAFIRRCLAYRKEDRID--------------VQQLACDPYL
Activation segment
DFGLSKIMDDDSYN--SVDGMELT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGAGTYWYLPPE
Binding pocket
HLLGRGGFSEVYKVAVKIHHACREYRIHKELDPRIVKLYDYCTVLEYCEGNDLDFYLKQNEIKPPIIHYDLKPGNILLITDFGLS
Ligand info
Orthosteric ligand
AGS
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5O0Y, Chain A