5NWZ Chain B
Fibroblast growth factor receptor 4 (FGFR4)
Inactive — 0.1%DFG-inαC-inType1.5_Back · 9CT
Resolution
2.37 Å
R-value
999.0
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms4
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSE
UniProt reference sequence
LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDK
Aligned reference sequence
LVLG----------------KPLGEGC----------------FGQVVRAEA--FGMDPARPD-----------------------------QASTVAVKMLK--DNASDKD---------------------------LADLVSEMEVMKLI--G-----------------------RHKNIINLLGVCTQEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVECAAK--------------GNLREFLRA--RRPPGPDLSPDGPRSSEG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSFPVLVSCAYQVARGMQYLESR---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLARGVHHIDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNGRLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGILLWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFSLLREG--HRMDRPPHCP-----------------------------------------------------------------------------------------------------PELYGLMRECWHAAPSQRPT--------------FKQLVEALDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------KPLGEGC----------------FGQVVRAEA--FGMDPARPD-----------------------------QASTVAVKMLK--DNASDKD---------------------------LADLVSEMEVMKLI--G-----------------------RHKNIINLLGVCTQEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVECAAK--------------GNLREFLRA--RRPP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSFPVLVSCAYQVARGMQYLESR---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGILLWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFSLLREG--HRMDRPPHCP-----------------------------------------------------------------------------------------------------PELYGLMRECWHAAPSQRPT--------------FKQLVEALDK
Activation segment
DF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRLPVKWMAPE
Binding pocket
KPLGEGCFGQVVRVAVKMLDLVSEMEVMKLIGKNIINLLGVYVIVECAAKGNLREFLRAYLESRKCIHRDLAARNVLVIADFG__
Ligand info
Orthosteric ligand
9CT
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5NWZ, Chain B