5MYV Chain B
SRSF protein kinase 2 (SRPK2)
Active — 98.8%DFG-inαC-inType1 · W4A
Resolution
2.9 Å
R-value
0.2
Predicted activity confidence98.8%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
YHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATELLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS
UniProt reference sequence
YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
Aligned reference sequence
YHVI----------------RKLGWGH----------------FSTVWLCWD--MQ------------------------------------GKRFVAMKVVK--SAQHY-----------------------------TETALDEIKLLKCV--RESDPSDP----------------NKDMVVQLIDDFKISG--MNGI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCMVFEVLG---------------HHLLKWIIK--SNYQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPVRCVKSIIRQVLQGLDYLHSK--C------------------------------------------KIIHTDI-----KPENILMCV--DDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNAD--KIRVKIADLGNACWVHKHF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEDIQTRQYRSIEVLIG--------------------------------AGYS-TPADIWSTACMAFELATG-----------------DYLFEP--HSGEDY------------------------------------------SRDEDHIAHIIEL--LGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDA------------------------------------------------------------AQFTDFLIPMLEMVPEKRAS--------------AGECLRHPWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YHVI----------------RKLGWGH----------------FSTVWLCWD--MQ------------------------------------GKRFVAMKVVK--SAQHY-----------------------------TETALDEIKLLKCV--RESDPSDP----------------NKDMVVQLIDDFKISG--MNGI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCMVFEVLG---------------HHLLKWIIK--SNYQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPVRCVKSIIRQVLQGLDYLHSK--C------------------------------------------KIIHTDI-----KPENILMCV--DDAYVRRMAAEATE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLVNPLDPRNAD--KIRVKIADLGNACWVHKHF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEDIQTRQYRSIEVLIG--------------------------------AGYS-TPADIWSTACMAFELATG-----------------DYLFEP--HSGEDY------------------------------------------SRDEDHIAHIIEL--LGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDA------------------------------------------------------------AQFTDFLIPMLEMVPEKRAS--------------AGECLRHPWL
Activation segment
DLGNACWVHKHF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEDIQTRQYRSIE
Binding pocket
RKLGWGHFSTVWLVAMKVVTALDEIKLLKCVRDMVVQLIDDCMVFEVLG_HHLLKWIIKLHSKCKIIHTDIKPENILMIADLGNA
Ligand info
Orthosteric ligand
W4A
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5MYV, Chain B