5MQV Chain F
Casein kinase I isoform delta (CSNK1D)
Active — 96.4%DFG-inαC-inType1 · D5Q
Resolution
2.15 Å
R-value
0.173
Predicted activity confidence96.4%
Structure info
Alternate conformationA
Missing atoms18
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
UniProt reference sequence
YRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRN
Aligned reference sequence
YRLG----------------RKIGSGS----------------FGDIYLGTD--IA------------------------------------AGEEVAIKLEC--VKTK------------------------------HPQLHIESKIYKMM--Q-----------------------GGVGIPTIRWCGAEGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVMVMELLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFSLKTVLLLADQMISRIEYIHSK---------------------------------------------NFIHRDV-----KPDNFLMGL--GKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNLVYIIDFGLAKKYRDARTH--QHIPYREN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASINTHLG--------------------------------IEQS-RRDDLESLGYVLMYFNLG-----------------SLPWQG--LKAATKR-----------------------------------------QKYERISEKKMST--PIEVLCKGYP-----------------------------------------------------------------------------------------------------SEFATYLNFCRSLRFDDKPD--------------YSYLRQLFRN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YRLG----------------RKIGSGS----------------FGDIYLGTD--IA------------------------------------AGEEVAIKLEC--VKTK------------------------------HPQLHIESKIYKMM--Q-----------------------GGVGIPTIRWCGAEGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVMVMELLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFSLKTVLLLADQMISRIEYIHSK---------------------------------------------NFIHRDV-----KPDNFLMGL--GKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNLVYIIDFGLAKKYRDARTH--QHIPYREN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASINTHLG--------------------------------IEQS-RRDDLESLGYVLMYFNLG-----------------SLPWQG--L--ATKR-----------------------------------------QKYERISEKKMST--PIEVLCKGYP-----------------------------------------------------------------------------------------------------SEFATYLNFCRSLRFDDKPD--------------YSYLRQLFRN
Activation segment
DFGLAKKYRDARTH--QHIPYREN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASIN
Binding pocket
RKIGSGSFGDIYLVAIKLEQLHIESKIYKMMQVGIPTIRWCVMVMELLG_PSLEDLFNFYIHSKNFIHRDVKPDNFLMIIDFGLA
Ligand info
Orthosteric ligand
D5Q
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5MQV, Chain F