5MJB Chain B
Ephrin type-B receptor 1 (EPHB1)
Active — 99.7%DFG-inαC-inType1 · 7O3
Resolution
2.23 Å
R-value
0.199
Predicted activity confidence99.7%
Structure info
Alternate conformation—
Missing atoms12
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
REFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLTSDPTTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKT
UniProt reference sequence
VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDK
Aligned reference sequence
VKIE----------------EVIGAGE----------------FGEVYKGRL--KLPGK---------------------------------REIYVAIKTLK--AGYSEKQ---------------------------RRDFLSEASIMGQF--------------------------DHPNIIRLEGVVTKSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEFMEN--------------GALDSFLRQ--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMKYLAEM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRYLQDDTSD--PTYTSS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGGKIPVRWTAPEAIAY--------------------------------RKFT-SASDVWSYGIVMWEVMSF--G--------------ERPYWD--------------------------------------------------MSNQDVINAIEQD--YRLPPPMDCP-----------------------------------------------------------------------------------------------------AALHQLMLDCWQKDRNSRPR--------------FAEIVNTLDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VKIE----------------EVIGAGE----------------FGEVYKGRL--KLPGK---------------------------------REI-VAIKTLK--AGYSEKQ---------------------------RRDFLSEASIMGQF--------------------------DHRNIIRLEGVVTKSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEFMEN--------------CALDSFLRQ--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMKYLSEM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRYL---TSD--PT-TSS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGGKIPVRWTAPEAIAY--------------------------------RKFT-SASDVWSYGIVMWEVMSF--G--------------ERPYWD--------------------------------------------------MSNQDVINAIEQD--YRLPPPMDCP-----------------------------------------------------------------------------------------------------AALHQLMLDCWQKDRNSRPR--------------FAEIVNTLDK
Activation segment
DFGLSRYL---TSD--PT-TSS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGGKIPVRWTAPE
Binding pocket
EVIGAGEFGEVYKVAIKTLDFLSEASIMGQFDRNIIRLEGVMIITEFMENCALDSFLRQYLSEMNYVHRDLAARNILVVSDFGLS
Ligand info
Orthosteric ligand
7O3
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5MJB, Chain B