5LOH Chain B
Serine/threonine-protein kinase greatwall (MASTL)
Inactive — 0.0%DFG-inαC-outType1 · STU
Resolution
3.1 Å
R-value
0.209
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms23
Missing residues9
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
PSIEEFSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFIPQP
UniProt reference sequence
FSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFNTPIAEKNQDPANILSACLSETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQSRKRLATSSASSQSHTFISSVESECHSSPKWEKDCQESDEALGPTMMSWNAVEKLCAKSANAIETKGFNKKDLELALSPIHNSSALPTTGRSCVNLAKKCFSGEVSWEAVELDVNNINMDTDTSQLGFHQSNQWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKKTCVEYKHNEMTNCYTNQNTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQQTPEKLPIPMIAKNLMCELDEDCEKNSKRDYLSSSFLCSDDDRASKNISMNSDSSFPGISIMESPLESQPLDSDRSIKESSFEESNIEDPLIVTPDCQEKTSPKGVENPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFNSHINASNNSEPSRMNMTSLDAMDISCAYSGSYPMAITPTQKRRSCMPHQQTPNQIKSGTPYRTPKSVRRGVAPVDDGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLF
Aligned reference sequence
FSIV----------------KPISRGA----------------FGKVYLGQK----------------------------------------GGKLYAVKVVK--KADMINKNM-------------------------THQVQAERDALALS--------------------------KSPFIVHLYYSLQSAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVYLVMEYLIG--------------GDVKSLLHI--YG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YFDEEMAVKYISEVALALDYLHRH---------------------------------------------GIIHRDL-----KPDNMLISN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKLTDFGLSKVTLNRDIN--MMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFNTPIAEKNQDPANILSACLSETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQSRKRLATSSASSQSHTFISSVESECHSSPKWEKDCQESDEALGPTMMSWNAVEKLCAKSANAIETKGFNKKDLELALSPIHNSSALPTTGRSCVNLAKKCFSGEVSWEAVELDVNNINMDTDTSQLGFHQSNQWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKKTCVEYKHNEMTNCYTNQNTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQQTPEKLPIPMIAKNLMCELDEDCEKNSKRDYLSSSFLCSDDDRASKNISMNSDSSFPGISIMESPLESQPLDSDRSIKESSFEESNIEDPLIVTPDCQEKTSPKGVENPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFNSHINASNNSEPSRMNMTSLDAMDISCAYSGSYPMAITPTQKRRSCMPHQQTPNQIKSGTPYRTPKSVRRGVAPVDD--GRILGTPDYLAPELLLG--------------------------------RAHG-PAVDWWALGVCLFEFLTG-----------------IPPFND--------------------------------------------------ETPQQVFQNILKR--DIPWPEGEEKLS---------------------------------------------------------------------------------------------------DNAQSAVEILLTIDDTKRAG--------------MKELKRHPLF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FSIV----------------KPISRGA----------------FGKVYLGQK----------------------------------------GGKLYAVKVVK--KADMINK--------------------------------------ALS--------------------------KSPFIVHLYYSLQSAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVYLVMEYLIG--------------GDVKSLLHI--YG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YFDEEMAVKYISEVALALDYLHRH---------------------------------------------GIIHRDL-----KPDNMLISN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKLTDFG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGTPDYLAPELLLG--------------------------------RAHG-PAVDWWALGVCLFEFLTG-----------------IPPFND--------------------------------------------------ETPQQVFQNILKR--DIPWPEGEEKLS---------------------------------------------------------------------------------------------------DNAQSAVEILLTIDDTKRAG--------------MKELKRHPLF
Activation segment
DFG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGTPDYLAPE
Binding pocket
KPISRGAFGKVYLYAVKVV_________ALSKPFIVHLYYSYLVMEYLIGGDVKSLLHIYLHRHGIIHRDLKPDNMLILTDFGLG
Ligand info
Orthosteric ligand
STU
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5LOH, Chain B