5LOH Chain A
Serine/threonine-protein kinase greatwall (MASTL)
Inactive — 8.1%DFG-inαC-outType1 · STU
Resolution
3.1 Å
R-value
0.209
Predicted activity confidence8.1%
Structure info
Alternate conformationB
Missing atoms18
Missing residues12
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
PSIEEFSIVKPISGKVYLGQKGGKLYAVKVVKKADMLALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKFCGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFIPQP
UniProt reference sequence
FSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFNTPIAEKNQDPANILSACLSETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQSRKRLATSSASSQSHTFISSVESECHSSPKWEKDCQESDEALGPTMMSWNAVEKLCAKSANAIETKGFNKKDLELALSPIHNSSALPTTGRSCVNLAKKCFSGEVSWEAVELDVNNINMDTDTSQLGFHQSNQWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKKTCVEYKHNEMTNCYTNQNTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQQTPEKLPIPMIAKNLMCELDEDCEKNSKRDYLSSSFLCSDDDRASKNISMNSDSSFPGISIMESPLESQPLDSDRSIKESSFEESNIEDPLIVTPDCQEKTSPKGVENPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFNSHINASNNSEPSRMNMTSLDAMDISCAYSGSYPMAITPTQKRRSCMPHQQTPNQIKSGTPYRTPKSVRRGVAPVDDGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLF
Aligned reference sequence
FSIV----------------KPISRGA----------------FGKVYLGQK----------------------------------------GGKLYAVKVVK--KADMINKNM-------------------------THQVQAERDALALS--------------------------KSPFIVHLYYSLQSAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVYLVMEYLIG--------------GDVKSLLHI--YG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YFDEEMAVKYISEVALALDYLHRH---------------------------------------------GIIHRDL-----KPDNMLISN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKLTDFGLSKVTLNRDIN--MMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFNTPIAEKNQDPANILSACLSETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQSRKRLATSSASSQSHTFISSVESECHSSPKWEKDCQESDEALGPTMMSWNAVEKLCAKSANAIETKGFNKKDLELALSPIHNSSALPTTGRSCVNLAKKCFSGEVSWEAVELDVNNINMDTDTSQLGFHQSNQWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKKTCVEYKHNEMTNCYTNQNTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQQTPEKLPIPMIAKNLMCELDEDCEKNSKRDYLSSSFLCSDDDRASKNISMNSDSSFPGISIMESPLESQPLDSDRSIKESSFEESNIEDPLIVTPDCQEKTSPKGVENPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFNSHINASNNSEPSRMNMTSLDAMDISCAYSGSYPMAITPTQKRRSCMPHQQTPNQIKSGTPYRTPKSVRRGVAPVDD--GRILGTPDYLAPELLLG--------------------------------RAHG-PAVDWWALGVCLFEFLTG-----------------IPPFND--------------------------------------------------ETPQQVFQNILKR--DIPWPEGEEKLS---------------------------------------------------------------------------------------------------DNAQSAVEILLTIDDTKRAG--------------MKELKRHPLF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FSIV----------------KPIS--------------------GKVYLGQK----------------------------------------GGKLYAVKVVK--KADM----------------------------------------LALS--------------------------KSPFIVHLYYSLQSAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVYLVMEYLIG--------------GDVKSLLHI--YG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YFDEEMAVKYISEVALALDYLHRH---------------------------------------------GIIHRDL-----KPDNMLISN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKLTDFGLSK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FCGTPDYLAPELLLG--------------------------------RAHG-PAVDWWALGVCLFEFLTG-----------------IPPFND--------------------------------------------------ETPQQVFQNILKR--DIPWPEGEEKLS---------------------------------------------------------------------------------------------------DNAQSAVEILLTIDDTKRAG--------------MKELKRHPLF
Activation segment
DFGLSK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FCGTPDYLAPE
Binding pocket
KPIS____GKVYLYAVKVV________LALSKPFIVHLYYSYLVMEYLIGGDVKSLLHIYLHRHGIIHRDLKPDNMLILTDFGLS
Ligand info
Orthosteric ligand
STU
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5LOH, Chain A