5L6W Chain L
LIM domain kinase 1 (LIMK1)
Active — 97.4%DFG-inαC-inATPlike · AGS
Resolution
2.53 Å
R-value
0.229
Predicted activity confidence97.4%
Structure info
Alternate conformation—
Missing atoms31
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SMPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYR
UniProt reference sequence
LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLET
Aligned reference sequence
LIHG----------------EVLGKGC----------------FGQAIKVTH--RE------------------------------------TGEVMVMKELI--RFDEET----------------------------QRTFLKEVKVMRCL--------------------------EHPNVLKFIGVLYKDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLNFITEYIKG--------------GTLRGIIKS--MDS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QYPWSQRVSFAKDIASGMAYLHSM---------------------------------------------NIIHRDL-----NSHNCLVRE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKNVVVADFGLARLMVDEKTQ--PEGLRSLKKPDRKKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTVVGNPYWMAPEMING--------------------------------RSYD-EKVDVFSFGIVLCEIIGR-------------------------VNADPDYLPRTM------------------------------------DFGLNVRGFLDRY--CPPNCP---------------------------------------------------------------------------------------------------------PSFFPITVRCCDLDPEKRPS--------------FVKLEHWLET
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LIHG----------------EVLGKGC----------------FGQAIKVTH--RE------------------------------------TGEVMVMKELI--RFDEET----------------------------QRTFLKEVKVMRCL--------------------------EHPNVLKFIGVLYKDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLNFITEYIKG--------------GTLRGIIKS--MDS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QYPWSQRVSFAKDIASGMAYLHSM---------------------------------------------NIIHRDL-----NSHNCLVRE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKNVVVADFGLARLM------------------DRKKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTVVGNPYWMAPEMING--------------------------------RSYD-EKVDVFSFGIVLCEIIGR-------------------------VNADPDYLPRTM------------------------------------DFGLNVRGFLDRY--CPPNCP---------------------------------------------------------------------------------------------------------PSFFPITVRCCDLDPEKRPS--------------FVKLEHWLET
Activation segment
DFGLARLM------------------DRKKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTVVGNPYWMAPE
Binding pocket
EVLGKGCFGQAIKMVMKELTFLKEVKVMRCLEPNVLKFIGVNFITEYIKGGTLRGIIKSYLHSMNIIHRDLNSHNCLVVADFGLA
Ligand info
Orthosteric ligand
AGS
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5L6W, Chain L