5L6P Chain A
Ephrin type-B receptor 3 (EPHB3)
Inactive — 0.4%DFG-outαC-inType1 · 6P8
Resolution
2.26 Å
R-value
0.206
Predicted activity confidence0.4%
Structure info
Alternate conformation—
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
CVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNPASLKVI
UniProt reference sequence
VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDK
Aligned reference sequence
VKIE----------------EVIGAGE----------------FGEVCRGRL--KQPGR---------------------------------REVFVAIKTLK--VGYTERQ---------------------------RRDFLSEASIMGQF--------------------------DHPNIIRLEGVVTKSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMILTEFMEN--------------CALDSFLRL--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMKYLSEM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRFLEDDPSD--PTYTSS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGGKIPIRWTAPEAIAY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MSNQDVINAVEQD--YRLPPPMDCP-----------------------------------------------------------------------------------------------------TALHQLMLDCWVRDRNLRPK--------------FSQIVNTLDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VKIE----------------EVIGAGE----------------FGEVCRGRL--KQPGR---------------------------------REVFVAIKTLK--VGYTERQ---------------------------RRDFLSEASIMGQF--------------------------DHPNIIRLEGVVTKSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMILTEFMEN--------------CALDSFLRL--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMKYLSEM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRFLEDDPSD--PTYTSS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGGKIPIRWTAPEAIAY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MSNQDVINAVEQD--YRLPPPMDCP-----------------------------------------------------------------------------------------------------TALHQLMLDCWVRDRNLRPK--------------FSQIVNTLDK
Activation segment
DFGLSRFLEDDPSD--PTYTSS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGGKIPIRWTAPE
Binding pocket
EVIGAGEFGEVCRVAIKTLDFLSEASIMGQFDPNIIRLEGVMILTEFMENCALDSFLRLYLSEMNYVHRDLAARNILVVSDFGLS
Ligand info
Orthosteric ligand
6P8
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5L6P, Chain A