5L2Q Chain C
Serine/threonine-protein kinase 40 (STK40)
Active — 98.0%DFG-inαC-out
Resolution
2.53 Å
R-value
0.259
Predicted activity confidence98.0%
Structure info
Alternate conformationB
Missing atoms38
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LGPRLGNSPVPSIVQCLARKYQLKILTLESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSAIIASW
UniProt reference sequence
FILGPRLGNSPVPSIVQCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSA
Aligned reference sequence
FILG----------------PRLGNSP-VP-------------SIVQCLARK--DG------------------------------------TDDFYQLKILT--LEERGDQGIESQEERQG-----------------KMLLHTEYSLLSLL--H-----------------------TQDGVVHHHGLFQDRT--CEIVEDTESSRMVKKMKK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RICLVLDCLCA--HDFSDKTADL--INLQHYVIK--EK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLSERETVVIFYDVVRVVEALHQK---------------------------------------------NIVHRDL-----KLGNMVLNK--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THRITITNFCLGKHLVSEGDL--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDQRGSPAYISPDVLSG--------------------------------RPYRGKPSDMWALGVVLFTMLYG-----------------QFPFYD--------------------------------------------------SIPQELFRKIKAA--EYTIPEDGRVS----------------------------------------------------------------------------------------------------ENTVCLIRKLLVLDPQQRLA--------------AADVLEALSA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
--LG----------------PRLGNSP-VP-------------SIVQCLARK--------------------------------------------YQLKILT--L--------ESQEERQG-----------------KMLLHTEYSLLSLL--H-----------------------TQDGVVHHHGLFQDRT--CEIVEDTESSRMV---KK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RICLVLDCLCA--HDFSDKTADL--INLQHYVIK--EK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLSERETVVIFYDVVRVVEALHQK---------------------------------------------NIVHRDL-----KLGNMVLNK--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THRITITNFCLGKHLVSEGDL--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDQRGSPAYISPDVLSG--------------------------------RPYRGKPSDMWALGVVLFTMLYG-----------------QFPFYD--------------------------------------------------SIPQELFRKIKAA--EYTIPEDGRVS----------------------------------------------------------------------------------------------------ENTVCLIRKLLVLDPQQRLA--------------AADVLEALSA
Activation segment
NFCLGKHLVSEGDL--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDQRGSPAYISPD
Binding pocket
_______________________________LRQGKMLLHTFSDKTADLNLQHYVIKEKALHQKNIVHRDLKLGNMVLITNFCLG
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5L2Q, Chain C