5L2Q Chain B
Serine/threonine-protein kinase 40 (STK40)
Active — 99.8%DFG-inαC-out
Resolution
2.53 Å
R-value
0.259
Predicted activity confidence99.8%
Structure info
Alternate conformationA
Missing atoms17
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
KRAGPFILGPRLGNSPVPSIVQCLARKDGTDDFYQLKILTLSQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSAIIASWQ
UniProt reference sequence
FILGPRLGNSPVPSIVQCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSA
Aligned reference sequence
FILG----------------PRLGNSP-VP-------------SIVQCLARK--DG------------------------------------TDDFYQLKILT--LEERGDQGIESQEERQG-----------------KMLLHTEYSLLSLL--H-----------------------TQDGVVHHHGLFQDRT--CEIVEDTESSRMVKKMKK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RICLVLDCLCA--HDFSDKTADL--INLQHYVIK--EK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLSERETVVIFYDVVRVVEALHQK---------------------------------------------NIVHRDL-----KLGNMVLNK--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THRITITNFCLGKHLVSEGDL--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDQRGSPAYISPDVLSG--------------------------------RPYRGKPSDMWALGVVLFTMLYG-----------------QFPFYD--------------------------------------------------SIPQELFRKIKAA--EYTIPEDGRVS----------------------------------------------------------------------------------------------------ENTVCLIRKLLVLDPQQRLA--------------AADVLEALSA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FILG----------------PRLGNSP-VP-------------SIVQCLARK--DG------------------------------------TDDFYQLKILT--L---------SQEERQG-----------------KMLLHTEYSLLSLL--H-----------------------TQDGVVHHHGLFQDRT--C----------------K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RICLVLDCLCA--HDFSDKTADL--INLQHYVIK--EK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLSERETVVIFYDVVRVVEALHQK---------------------------------------------NIVHRDL-----KLGNMVLNK--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THRITITNFCLGKHLVSEGDL--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDQRGSPAYISPDVLSG--------------------------------RPYRGKPSDMWALGVVLFTMLYG-----------------QFPFYD--------------------------------------------------SIPQELFRKIKAA--EYTIPEDGRVS----------------------------------------------------------------------------------------------------ENTVCLIRKLLVLDPQQRLA--------------AADVLEALSA
Activation segment
NFCLGKHLVSEGDL--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDQRGSPAYISPD
Binding pocket
________________________________FYQLKILTLFSDKTADLNLQHYVIKEKALHQKNIVHRDLKLGNMVLITNFCLG
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5L2Q, Chain B