5KMO Chain A
High affinity nerve growth factor receptor (NTRK1)
Active — 78.6%DFG-outαC-inType1 · 6UM
Resolution
2.67 Å
R-value
0.196
Predicted activity confidence78.6%
Structure info
Alternate conformation—
Missing atoms22
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLGH
UniProt reference sequence
IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA
Aligned reference sequence
IVLK----------------WELGEGA----------------FGKVFLAEC--HNLLPEQ-------------------------------DKMLVAVKALK--EASESA----------------------------RQDFQREAELLTML--------------------------QHQHIVRFFGVCTEGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLMVFEYMRH--------------GDLNRFLRS--HGPDAKLLAGGEDVAPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGLGQLLAVASQVAAGMVYLAGL---------------------------------------------HFVHRDL-----ATRNCLVGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLVVKIGDFGMSRDIYSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRTMLPIRWMPPESILY--------------------------------RKFT-TESDVWSFGVVLWEIFTY--G--------------KQPWYQ--------------------------------------------------LSNTEAIDCITQG--RELERPRACP-----------------------------------------------------------------------------------------------------PEVYAIMRGCWQREPQQRHS--------------IKDVHARLQA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IVLK----------------WELGEGA----------------FGKVFLAEC--HNLLPEQ-------------------------------DKMLVAVKALK-----ESA----------------------------RQDFQREAELLTML--------------------------QHQHIVRFFGVCTEGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLMVFEYMRH--------------GDLNRFLRS--HGPDAKL--GGEDVAPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGLGQLLAVASQVAAGMVYLAGL---------------------------------------------HFVHRDL-----ATRNCLVGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLVVKIGDFG--RDIYSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRTMLPIRWMPPESILY--------------------------------RKFT-TESDVWSFGVVLWEIFTY--G--------------KQPWYQ--------------------------------------------------LSNTEAIDCITQG--RELERPRACP-----------------------------------------------------------------------------------------------------PEVYAIMRGCWQREPQQRHS--------------IKDVHARLQA
Activation segment
DFG--RDIYSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRTMLPIRWMPPE
Binding pocket
WELGEGAFGKVFLVAVKALDFQREAELLTMLQQHIVRFFGVLMVFEYMRHGDLNRFLRSYLAGLHFVHRDLATRNCLVIGDFG__
Ligand info
Orthosteric ligand
6UM
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5KMO, Chain A