5KKR Chain B
Kinase suppressor of Ras 2 (KSR2)
Inactive — 0.0%DFG-inαC-outType1.5_Back · 6U7
Resolution
3.51 Å
R-value
0.252
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms6
Missing residues3
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
SQTSIFLQEWDIPFEQLEIGELIGFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQDKLRIQNGWLCHLAPEIIRQLSPDDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLP
UniProt reference sequence
LEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEK
Aligned reference sequence
LEIG----------------ELIGKGR----------------FGQVYHGRW-----------------------------------------HGEVAIRLID--IERDNEDQ--------------------------LKAFKREVMAYRQT--------------------------RHENVVLFMGACMSPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLAIITSLCKG--------------RTLYSVVRD--AKI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLDVNKTRQIAQEIVKGMGYLHAK---------------------------------------------GILHKDL-----KSKNVFYD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGKVVITDFGLFSISGVLQAG--RREDKL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIQNGWLCHLAPEIIRQ--LSPDTEEDK---------------------LPFS-KHSDVFALGTIWYELHAR-----------------EWPFKT--------------------------------------------------QPAEAIIWQMGTG--MKPNLSQIGMG----------------------------------------------------------------------------------------------------KEISDILLFCWAFEQEERPT--------------FTKLMDMLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LEIG----------------ELIG-------------------FGQVYHGRW-----------------------------------------HGEVAIRLID--IERDNEDQ--------------------------LKAFKREVMAYRQT--------------------------RHENVVLFMGACMSPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLAIITSLCKG--------------RTLYSVVRD--AKI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLDVNKTRQIAQEIVKGMGYLHAK---------------------------------------------GILHKDL-----KSKNVFYD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGKVVITDFGLFSISGVLQ-------DKL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIQNGWLCHLAPEIIRQ--LSPD---DK---------------------LPFS-KHSDVFALGTIWYELHAR-----------------EWPFKT--------------------------------------------------QPAEAIIWQMGTG--MKPNLSQIGMG----------------------------------------------------------------------------------------------------KEISDILLFCWAFEQEERPT--------------FTKLMDMLEK
Activation segment
DFGLFSISGVLQ-------DKL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIQNGWLCHLAPE
Binding pocket
ELIG___FGQVYHVAIRLIAFKREVMAYRQTRENVVLFMGAAIITSLCKGRTLYSVVRDYLHAKGILHKDLKSKNVFYITDFGLF
Ligand info
Orthosteric ligand
6U7
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5KKR, Chain B