5K75 Chain D
Interleukin-1 receptor-associated kinase 4 (IRAK4)
Active — 97.6%DFG-inαC-inType1 · 6QX
Resolution
2.03 Å
R-value
0.24
Predicted activity confidence97.6%
Structure info
Alternate conformationB
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
RFHSFSFYELKNVTNNFDERPISVGGNKMGEFGVVYKGYVNNTTVAVKKLTTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASTVMRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT
UniProt reference sequence
NVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQE
Aligned reference sequence
NVT---NNFDERPISVGG--NKMGEGG----------------FGVVYKGYV----------------------------------------NNTTVAVKKLA--AMVDITTEEL------------------------KQQFDQEIKVMAKC--------------------------QHENLVELLGFSSDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLCLVYVYMPN--------------GSLLDRLSC--LDGTP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN---------------------------------------------HHIHRDI-----KSANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFTAKISDFGLARASEKFAQT--VMT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRIVGTTAYMAPEALR---------------------------------GEIT-PKSDIYSFGVVLLEIITG-----------------LPAVDE--HREP--------------------------------------------QLLLDIKEEIEDE--EKTIEDYIDKKMNDADSTSV-------------------------------------------------------------------------------------------EAMYSVASQCLHEKKNKRPD--------------IKKVQQLLQE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
NVT---NNFDERPISVGG--NKMGE------------------FGVVYKGYV----------------------------------------NNTTVAVKKL--------TTEEL------------------------KQQFDQEIKVMAKC--------------------------QHENLVELLGFSSDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLCLVYVYMPN--------------GSLLDRLSC--LDGTP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN---------------------------------------------HHIHRDI-----KSANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFTAKISDFGLARAS-----T--VM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIVGTTAYMAPEALR---------------------------------GEIT-PKSDIYSFGVVLLEIITG-----------------LPAVDE--HREP--------------------------------------------QLLLDIKEEIEDE--EKTIEDYIDKKMNDADSTSV-------------------------------------------------------------------------------------------EAMYSVASQCLHEKKNKRPD--------------IKKVQQLLQE
Activation segment
DFGLARAS-----T--VM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIVGTTAYMAPE
Binding pocket
NKMGE__FGVVYKVAVKKLQFDQEIKVMAKCQENLVELLGFCLVYVYMPNGSLLDRLSCFLHENHHIHRDIKSANILLISDFGLA
Ligand info
Orthosteric ligand
6QX
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5K75, Chain D