5K0X Chain B
Tyrosine-protein kinase Mer (MERTK)
Inactive — 0.0%DFG-outαC-outType1 · K0X
Resolution
2.23 Å
R-value
0.189
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues7
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
NKLEDVVIDRNLLILGKILGEFGSVMEGNLKQEDGTSLKVAVKTEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPD
UniProt reference sequence
LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEK
Aligned reference sequence
LILG----------------KILGEGE----------------FGSVMEGNL--KQEDG---------------------------------TSLKVAVKTMK--LDNSSQRE--------------------------IEEFLSEAACMKDF--------------------------SHPNVIRLLGVCIEMS--SQGIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPMVILPFMKY--------------GDLHTYLLY--SRLETGPK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIPLQTLLKFMVDIALGMEYLSNR---------------------------------------------NFLHRDL-----AARNCMLRD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADFGLSKKIYSGDYY--RQG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIAKMPVKWIAIESLAD--------------------------------RVYT-SKSDVWAFGVTMWEIATR--G--------------MTPYPG--------------------------------------------------VQNHEMYDYLLHG--HRLKQPEDCL-----------------------------------------------------------------------------------------------------DELYEIMYSCWRTDPLDRPT--------------FSVLRLQLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LILG----------------KIL--GE----------------FGSVMEGNL--KQEDG---------------------------------TSLKVAVKT----------------------------------------EFLSEAACMKDF--------------------------SHPNVIRLLGVCIEMS--SQGIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPMVILPFMKY--------------GDLHTYLLY--SRLETGPK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIPLQTLLKFMVDIALGMEYLSNR---------------------------------------------NFLHRDL-----AARNCMLRD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVAD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWIAIESLAD--------------------------------RVYT-SKSDVWAFGVTMWEIATR--G--------------MTPYPG--------------------------------------------------VQNHEMYDYLLHG--HRLKQPEDCL-----------------------------------------------------------------------------------------------------DELYEIMYSCWRTDPLDRPT--------------FSVLRLQLEK
Activation segment
D------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWIAIE
Binding pocket
KILGE__FGSVMEVAVKT_EFLSEAACMKDFSPNVIRLLGVMVILPFMKYGDLHTYLLYYLSNRNFLHRDLAARNCMLVAD____
Ligand info
Orthosteric ligand
K0X
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5K0X, Chain B