5JFX Chain A
High affinity nerve growth factor receptor (NTRK1)
Inactive — 0.0%DFG-outαC-inType2 · 6K4
Resolution
1.63 Å
R-value
0.203
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
MHHHHHHLVPRGSVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLD
UniProt reference sequence
IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA
Aligned reference sequence
IVLK----------------WELGEGA----------------FGKVFLAEC--HNLLPEQ-------------------------------DKMLVAVKALK--EASESA----------------------------RQDFQREAELLTML--------------------------QHQHIVRFFGVCTEGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLMVFEYMRH--------------GDLNRFLRS--HGPDAKLLAGGEDVAPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGLGQLLAVASQVAAGMVYLAGL---------------------------------------------HFVHRDL-----ATRNCLVGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLVVKIGDFGMSRDIYSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRTMLPIRWMPPESILY--------------------------------RKFT-TESDVWSFGVVLWEIFTY--G--------------KQPWYQ--------------------------------------------------LSNTEAIDCITQG--RELERPRACP-----------------------------------------------------------------------------------------------------PEVYAIMRGCWQREPQQRHS--------------IKDVHARLQA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IVLK----------------WELGEGA----------------FGKVFLAEC--HNLLPEQ-------------------------------DKMLVAVKALK--EASESA----------------------------RQDFQREAELLTML--------------------------QHQHIVRFFGVCTEGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLMVFEYMRH--------------GDLNRFLRS--HGP----------VAPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGLGQLLAVASQVAAGMVYLAGL---------------------------------------------HFVHRDL-----ATRNCLVGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLVVKIGDFG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPIRWMPPESILY--------------------------------RKFT-TESDVWSFGVVLWEIFTY--G--------------KQPWYQ--------------------------------------------------LSNTEAIDCITQG--RELERPRACP-----------------------------------------------------------------------------------------------------PEVYAIMRGCWQREPQQRHS--------------IKDVHARLQA
Activation segment
DFG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPIRWMPPE
Binding pocket
WELGEGAFGKVFLVAVKALDFQREAELLTMLQQHIVRFFGVLMVFEYMRHGDLNRFLRSYLAGLHFVHRDLATRNCLVIGDFG__
Ligand info
Orthosteric ligand
6K4
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5JFX, Chain A