5J8I Chain A
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)
Inactive — 0.0%DFG-outαC-inType1 · 6H4
Resolution
2.4 Å
R-value
0.224
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues7
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SLHMIDYKEIEVEEVVGRFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGCLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQHSLPPGEDGRVEPYVDFAEFYRLWSVDHG
UniProt reference sequence
IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTH
Aligned reference sequence
IEVE----------------EVVGRGA----------------FGVVCKAKW----------------------------------------RAKDVAIKQIE--SESE------------------------------RKAFIVELRQLSRV--------------------------NHPNIVKLYGACLN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVCLVMEYAEG--------------GSLYNVLHG--AEPLP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYTAAHAMSWCLQCSQGVAYLHSM--QPK----------------------------------------ALIHRDL-----KPPNLLLVA--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVLKICDFGTACDIQTHM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNNKGSAAWMAPEVFEG--------------------------------SNYS-EKCDVFSWGIILWEVITR-----------------RKPFDE--IG----------------------------------------------GPAFRIMWAVHNG--TRPPLIKNLP-----------------------------------------------------------------------------------------------------KPIESLMTRCWSKDPSQRPS--------------MEEIVKIMTH
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IEVE----------------EVVGR------------------FGVVCKAKW----------------------------------------RAKDVAIKQIE--SESE------------------------------RKAFIVELRQLSRV--------------------------NHPNIVKLYG-CLN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVCLVMEYAEG--------------GSLYNVLHG--AEPLP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYTAAHAMSWCLQCSQGVAYLHSM--QPK----------------------------------------ALIHRDL-----KPPNLLLVA--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVLKICD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSAAWMAPEVFEG--------------------------------SNYS-EKCDVFSWGIILWEVITR-----------------RKPFDE--IG----------------------------------------------GPAFRIMWAVHNG--TRPPLIKNLP-----------------------------------------------------------------------------------------------------KPIESLMTRCWSKDPSQRPS--------------MEEIVKIMTH
Activation segment
D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSAAWMAPE
Binding pocket
EVVGR__FGVVCKVAIKQIAFIVELRQLSRVNPNIVKLYG_CLVMEYAEGGSLYNVLHGSMQPKALIHRDLKPPNLLLICD____
Ligand info
Orthosteric ligand
6H4
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5J8I, Chain A