5J7S Chain A
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)
Inactive — 0.0%DFG-outαC-outType1 · 6H3
Resolution
2.37 Å
R-value
0.229
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues8
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SLHMIDYKEIEVEEVVGRGGVVCKAKWRAKDVAIKKAFIVELRQLSRVNHPNIVKLYLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQHSLPPGEDGRVEPYVDFAEFYRLWSVDHG
UniProt reference sequence
IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTH
Aligned reference sequence
IEVE----------------EVVGRGA----------------FGVVCKAKW----------------------------------------RAKDVAIKQIE--SESE------------------------------RKAFIVELRQLSRV--------------------------NHPNIVKLYGACLN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVCLVMEYAEG--------------GSLYNVLHG--AEPLP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYTAAHAMSWCLQCSQGVAYLHSM--QPK----------------------------------------ALIHRDL-----KPPNLLLVA--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVLKICDFGTACDIQTHM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNNKGSAAWMAPEVFEG--------------------------------SNYS-EKCDVFSWGIILWEVITR-----------------RKPFDE--IG----------------------------------------------GPAFRIMWAVHNG--TRPPLIKNLP-----------------------------------------------------------------------------------------------------KPIESLMTRCWSKDPSQRPS--------------MEEIVKIMTH
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IEVE----------------EVVGRG------------------GVVCKAKW----------------------------------------RAKDVAIK----------------------------------------KAFIVELRQLSRV--------------------------NHPNIVKLY---LN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVCLVMEYAEG--------------GSLYNVLHG--AEPLP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYTAAHAMSWCLQCSQGVAYLHSM--QPK----------------------------------------ALIHRDL-----KPPNLLLVA--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVLKICDF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSAAWMAPEVFEG--------------------------------SNYS-EKCDVFSWGIILWEVITR-----------------RKPFDE--IG----------------------------------------------GPAFRIMWAVHNG--TRPPLIKNLP-----------------------------------------------------------------------------------------------------KPIESLMTRCWSKDPSQRPS--------------MEEIVKIMTH
Activation segment
DF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSAAWMAPE
Binding pocket
EVVGRG__GVVCKVAIK__AFIVELRQLSRVNPNIVKLY__CLVMEYAEGGSLYNVLHGSMQPKALIHRDLKPPNLLLICDFG__
Ligand info
Orthosteric ligand
6H3
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5J7S, Chain A