5J5T Chain A
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)
Inactive — 1.1%DFG-inαC-inType1 · 6G2
Resolution
2.85 Å
R-value
0.177
Predicted activity confidence1.1%
Structure info
Alternate conformation—
Missing atoms3
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLDNGHVKLADFGVSAQITATIAAFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPSTYHDFDDDDPEPLVAVPHR
UniProt reference sequence
FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV
Aligned reference sequence
FELI----------------QRIGSGT----------------YGDVYKARN--VN------------------------------------TGELAAIKVIK--LEPGED----------------------------FAVVQQEIIMMKDC--------------------------KHPNIVAYFGSYLRRD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWICMEFCGG--------------GSLQDIYHV--TG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSELQIAYVSRETLQGLYYLHSK---------------------------------------------GKMHRDI-----KGANILLTD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGHVKLADFGVSAQITATIAK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSFIGTPYWMAPEVAAV--ERK---------------------------GGYN-QLCDLWAVGITAIELAEL-----------------QPPMFD--------------------------------------------------LHPMRALFLMTKS--NFQPPKLKDKMKWS-------------------------------------------------------------------------------------------------NSFHHFVKMALTKNPKKRPT--------------AEKLLQHPFV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELI----------------QRIGSGT----------------YGDVYKARN--VN------------------------------------TGELAAIKVIK--LEPGED----------------------------FAVVQQEIIMMKDC--------------------------KHPNIVAYFGSYLRRD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWICMEFCGG--------------GSLQDIYHV--TG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSELQIAYVSRETLQGLYYLHSK---------------------------------------------GKMHRDI-----KGANILL-D--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGHVKLADFGVSAQITATIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFIGTPYWMAPEVAAV--ERK---------------------------GGYN-QLCDLWAVGITAIELAEL-----------------QPPMFD--------------------------------------------------LHPMRALFLMTKS--NFQPPKLKDKMKWS-------------------------------------------------------------------------------------------------NSFHHFVKMALTKNPKKRPT--------------AEKLLQHPFV
Activation segment
DFGVSAQITATIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFIGTPYWMAPE
Binding pocket
QRIGSGTYGDVYKAAIKVIVVQQEIIMMKDCKPNIVAYFGSWICMEFCGGGSLQDIYHVYLHSKGKMHRDIKGANILLLADFGVS
Ligand info
Orthosteric ligand
6G2
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5J5T, Chain A