5I3R Chain B
BMP-2-inducible protein kinase (BMP2K)
Active — 99.6%DFG-inαC-inType1 · IDK
Resolution
2.4 Å
R-value
0.188
Predicted activity confidence99.6%
Structure info
Alternate conformation—
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
RVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAAADCPVSNINNSSIPSALPEPMTA
UniProt reference sequence
VTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFK
Aligned reference sequence
VTLE----------------ESLAEGG----------------FSTVFLVRT--H-------------------------------------GGIRCALKRMY--VNNMPD----------------------------LNVCKREITIMKEL--S-----------------------GHKNIVGYLDCAVNSI--SDNVW-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVLILMEYCRA--------------GQVVNQMNK--KLQT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFTEPEVLQIFCDTCEAVARLHQC--KT-----------------------------------------PIIHRDL-----KVENILLND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGNYVLCDFGSATNKFLNPQK--DGVNVVEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKKYTTLSYRAPEMINL--YGG---------------------------KPIT-TKADIWALGCLLYKLCFF-----------------TLPFGE-------------------------------------------------------SQVAICDG--NFTIPDNSRYS----------------------------------------------------------------------------------------------------RNIHCLIRFMLEPDPEHRPD--------------IFQVSYFAFK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VTLE----------------ESLAEGG----------------FSTVFLVRT--H-------------------------------------GGIRCALKRMY--VNNMPD----------------------------LNVCKREITIMKEL--S-----------------------GHKNIVGYLDCAVNSI--SDNVW-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVLILMEYCRA--------------GQVVNQMNK--KLQT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFTEPEVLQIFCDTCEAVARLHQC--KT-----------------------------------------PIIHRDL-----KVENILLND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGNYVLCDFGSATNKFLNPQK--DGVNVVEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKKYTTLSYRAPEMINL--YGG---------------------------KPIT-TKADIWALGCLLYKLCFF-----------------TLPFGE-------------------------------------------------------SQVAICDG--NFTIPDNSRYS----------------------------------------------------------------------------------------------------RNIHCLIRFMLEPDPEHRPD--------------IFQVSYFAFK
Activation segment
DFGSATNKFLNPQK--DGVNVVEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKKYTTLSYRAPE
Binding pocket
ESLAEGGFSTVFLCALKRMVCKREITIMKELSKNIVGYLDCLILMEYCRAGQVVNQMNKHQCKTPIIHRDLKVENILLLCDFGSA
Ligand info
Orthosteric ligand
IDK
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5I3R, Chain B