5HVK Chain A
LIM domain kinase 1 (LIMK1)
Active — 99.4%DFG-inαC-inATPlike · ANP
Resolution
3.5 Å
R-value
0.275
Predicted activity confidence99.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GAMGSRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDPDRKKRYVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRR
UniProt reference sequence
LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLET
Aligned reference sequence
LIHG----------------EVLGKGC----------------FGQAIKVTH--RE------------------------------------TGEVMVMKELI--RFDEET----------------------------QRTFLKEVKVMRCL--------------------------EHPNVLKFIGVLYKDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLNFITEYIKG--------------GTLRGIIKS--MDS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QYPWSQRVSFAKDIASGMAYLHSM---------------------------------------------NIIHRDL-----NSHNCLVRE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKNVVVADFGLARLMVDEKTQ--PEGLRSLKKPDRKKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTVVGNPYWMAPEMING--------------------------------RSYD-EKVDVFSFGIVLCEIIGR-------------------------VNADPDYLPRTM------------------------------------DFGLNVRGFLDRY--CPPNCP---------------------------------------------------------------------------------------------------------PSFFPITVRCCDLDPEKRPS--------------FVKLEHWLET
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LIHG----------------EVLGKGC----------------FGQAIKVTH--RE------------------------------------TGEVMVMKELI--RFDEET----------------------------QRTFLKEVKVMRCL--------------------------EHPNVLKFIGVLYKDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLNFITEYIKG--------------GTLRGIIKS--MDS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QYPWSQRVSFAKDIASGMAYLHSM---------------------------------------------NIIHRNL-----NSHNCLVRE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKNVVVADFGLARLMVD---------------PDRKKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VVGNPYWMAPEMING--------------------------------RSYD-EKVDVFSFGIVLCEIIGR-------------------------VNADPDYLPRTM------------------------------------DFGLNVRGFLDRY--CPPNCP---------------------------------------------------------------------------------------------------------PSFFPITVRCCDLDPEKRPS--------------FVKLEHWLET
Activation segment
DFGLARLMVD---------------PDRKKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VVGNPYWMAPE
Binding pocket
EVLGKGCFGQAIKMVMKELTFLKEVKVMRCLEPNVLKFIGVNFITEYIKGGTLRGIIKSYLHSMNIIHRNLNSHNCLVVADFGLA
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5HVK, Chain A