5HOA Chain A
Hepatocyte growth factor receptor (MET)
Inactive — 0.0%DFG-inαC-outType1 · 63K
Resolution
2.14 Å
R-value
999.0
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues9
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
AVQHVVVYHGTLKIHCAVKQFLTEGIIMKDFSHPNVLSLLGVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFVASKKFVHRDLAARNCMLDEKFTVKVADFGLARLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATY
UniProt reference sequence
LIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISA
Aligned reference sequence
LIVH--FN------------EVIGRGH----------------FGCVYHGTL--LDNDG---------------------------------KKIHCAVKSLN--RITDIGE---------------------------VSQFLTEGIIMKDF--------------------------SHPNVLSLLGICLRSE--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPLVVLPYMKH--------------GDLRNFIRN--ETH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPTVKDLIGFGLQVAKGMKYLASK---------------------------------------------KFVHRDL-----AARNCMLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTVKVADFGLARDMYDKEYY--SVHNK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGAKLPVKWMALESLQT--------------------------------QKFT-TKSDVWSFGVLLWELMTR--G--------------APPYPD--------------------------------------------------VNTFDITVYLLQG--RRLLQPEYCP-----------------------------------------------------------------------------------------------------DPLYEVMLKCWHPKAEMRPS--------------FSELVSRISA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
AVQH----------------------------------------VVVYHGTL-----------------------------------------KIHCAVK-----------------------------------------QFLTEGIIMKDF--------------------------SHPNVLSLLG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLPYMKH--------------GDLRNFIRN--ETH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPTVKDLIGFGLQVAKGMKFVASK---------------------------------------------KFVHRDL-----AARNCMLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTVKVADFGLAR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVKWMALESLQT--------------------------------QKFT-TKSDVWSFGVLLWELMTR--G--------------APPYPD--------------------------------------------------VNTFDITVYLLQG--RRLLQPEYCP-----------------------------------------------------------------------------------------------------DPLYEVMLKCWHPKAEMRPS--------------FSELVSRISA
Activation segment
DFGLAR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVKWMALE
Binding pocket
_AVQ__HV_VVYHCAVKQ__FLTEGIIMKDFSPNVLSLLG___VLPYMKHGDLRNFIRNFVASKKFVHRDLAARNCMLVADFGLA
Ligand info
Orthosteric ligand
63K
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5HOA, Chain A