5HG7 Chain A
Epidermal growth factor receptor (EGFR)
Inactive — 19.9%DFG-outαC-outType1 · 630
Resolution
1.85 Å
R-value
0.216
Predicted activity confidence19.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGD
UniProt reference sequence
FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSK
Aligned reference sequence
FKKI----------------KVLGSGA----------------FGTVYKGLW--IPEGEK--------------------------------VKIPVAIKELR--EATSPKA---------------------------NKEILDEAYVMASV--------------------------DNPHVCRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLITQLMPF--------------GCLLDYVRE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQYLLNWCVQIAKGMNYLEDR---------------------------------------------RLVHRDL-----AARNVLVKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQHVKITDFGLAKLLGAEEKE--YHA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGGKVPIKWMALESILH--------------------------------RIYT-HQSDVWSYGVTVWELMTF--G--------------SKPYDG--------------------------------------------------IPASEISSILEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK--------------FRELIIEFSK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKKI----------------KVLGSGA----------------FGTVYKGLW--IPEGEK--------------------------------VKIPVAIKELR-----SPKA---------------------------NKEILDEAYVMASV--------------------------DNPHVCRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLIMQLMPF--------------GCLLDYVRE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQYLLNWCVQIAKGMNYLEDR---------------------------------------------RLVHRDL-----AARNVLVKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQHVKITDFGRAKLLGAEEKE--YHA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGGKVPIKWMALESILH--------------------------------RIYT-HQSDVWSYGVTVWELMTF--G--------------SKPYDG--------------------------------------------------IPASEISSILEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMRKCWMIDADSRPK--------------FRELIIEFSK
Activation segment
DFGRAKLLGAEEKE--YHA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGGKVPIKWMALE
Binding pocket
KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLIMQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGRA
Ligand info
Orthosteric ligand
630
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5HG7, Chain A