5HES Chain B
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20)
Inactive — 0.2%DFG-inαC-outType1 · 032
Resolution
2.14 Å
R-value
0.18
Predicted activity confidence0.2%
Structure info
Alternate conformationB
Missing atoms2
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLE
UniProt reference sequence
LQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILES
Aligned reference sequence
LQFF----------------ENCGGGS----------------FGSVYRAKW--IS------------------------------------QDKEVAVKKLL--------------------------------------KIEKEAEILSVL--------------------------SHRNIIQFYGVILEPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYGIVTEYASL--------------GSLYDYINS--NRSE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMDMDHIMTWATDVAKGMHYLHME--APV----------------------------------------KVIHRDL-----KSRNVVIAA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGVLKICDFGASRFHNHTTH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSLVGTFPWMAPEVIQS--------------------------------LPVS-ETCDTYSYGVVLWEMLTR-----------------EVPFKG--------------------------------------------------LEGLQVAWLVVEK--NERLTIPSSCP----------------------------------------------------------------------------------------------------RSFAELLHQCWEADAKKRPS--------------FKQIISILES
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LQFF----------------ENCGGGS----------------FGSVYRAKW--IS------------------------------------QDKEVAVKKLL--------------------------------------KIEKEAEILSVL--------------------------SHRNIIQFYGVILEPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYGIVTEYASL--------------GSLYDYINS--NRSE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMDMDHIMTWATDVAKGMHYLHME--APV----------------------------------------KVIHRDL-----KSRNVVIAA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGVLKICDFG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTFPWMAPEVIQS--------------------------------LPVS-ETCDTYSYGVVLWEMLTR-----------------EVPFKG--------------------------------------------------LEGLQVAWLVVEK--NERLTIPSSCP----------------------------------------------------------------------------------------------------RSFAELLHQCWEADAKKRPS--------------FKQIISILES
Activation segment
DFG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTFPWMAPE
Binding pocket
ENCGGGSFGSVYRVAVKKLKIEKEAEILSVLSRNIIQFYGVGIVTEYASLGSLYDYINSMEAPVKVIHRDLKSRNVVIICDFG__
Ligand info
Orthosteric ligand
032
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5HES, Chain B