5HE1 Chain A
Beta-adrenergic receptor kinase 1 (GRK2)
Active — 64.2%DFG-inαC-inType1 · ZS2
Resolution
3.15 Å
R-value
0.172
Predicted activity confidence64.2%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKP
UniProt reference sequence
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF
Aligned reference sequence
FSVH----------------RIIGRGG----------------FGEVYGCRK--AD------------------------------------TGKMYAMKCLD--KKRIKMKQG-------------------------ETLALNERIMLSLV--STG---------------------DCPFIVCMSYAFHTPD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLSFILDLMNG--------------GDLHYHLSQ--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSEADMRFYAAEIILGLEHMHNR---------------------------------------------FVVYRDL-----KPANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGHVRISDLGLACDFSKKKP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HASVGTHGYMAPEVLQK--G-----------------------------VAYD-SSADWFSLGCMLFKLLRG-----------------HSPFRQ--HKT---------------------------------------------KDKHEIDRMTLTM--AVELPDSFS------------------------------------------------------------------------------------------------------PELRSLLEGLLQRDVNRRLG--CLGRG-------AQEVKESPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FSVH----------------RIIGRGG----------------FGEVYGCRK--AD------------------------------------TGKMYAMKCLD--KKRIKMKQG-------------------------ETLALNERIMLSLV--STG---------------------DCPFIVCMSYAFHTPD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLSFILDLMNG--------------GDLHYHLSQ--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSEADMRFYAAEIILGLEHMHNR---------------------------------------------FVVYRDL-----KPANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGHVRISDLGLACDFSKKKP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HASVGTHGYMAPEVLQK--G-----------------------------VAYD-SSADWFSLGCMLFKLLRG-----------------HSPFRQ--HKT---------------------------------------------KDKHEIDRMTLTM--AVELPDSFS------------------------------------------------------------------------------------------------------PELRSLLEGLLQRDVNRRLG--CLGRG-------AQEVKESPFF
Activation segment
DLGLACDFSKKKP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HASVGTHGYMAPE
Binding pocket
RIIGRGGFGEVYGYAMKCLLALNERIMLSLVSPFIVCMSYASFILDLMNGGDLHYHLSQHMHNRFVVYRDLKPANILLISDLGLA
Ligand info
Orthosteric ligand
ZS2
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5HE1, Chain A