5H3Q Chain A
High affinity nerve growth factor receptor (NTRK1)
Inactive — 0.0%DFG-outαC-inType1 · 7HF
Resolution
2.1 Å
R-value
0.19
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms3
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNKMLVAVKALKEARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
UniProt reference sequence
IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA
Aligned reference sequence
IVLK----------------WELGEGA----------------FGKVFLAEC--HNLLPEQ-------------------------------DKMLVAVKALK--EASESA----------------------------RQDFQREAELLTML--------------------------QHQHIVRFFGVCTEGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLMVFEYMRH--------------GDLNRFLRS--HGPDAKLLAGGEDVAPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGLGQLLAVASQVAAGMVYLAGL---------------------------------------------HFVHRDL-----ATRNCLVGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLVVKIGDFGMSRDIYSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRTMLPIRWMPPESILY--------------------------------RKFT-TESDVWSFGVVLWEIFTY--G--------------KQPWYQ--------------------------------------------------LSNTEAIDCITQG--RELERPRACP-----------------------------------------------------------------------------------------------------PEVYAIMRGCWQREPQQRHS--------------IKDVHARLQA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IVLK----------------WELGEGA----------------FGKVFLAEC--HN-------------------------------------KMLVAVKALK--E----A----------------------------RQDFQREAELLTML--------------------------QHQHIVRFFGVCTEGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLMVFEYMRH--------------GDLNRFLRS--HGPDAKLLAGGEDVAPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGLGQLLAVASQVAAGMVYLAGL---------------------------------------------HFVHRDL-----ATRNCLVGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLVVKIGDFGMSRDIYSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRTMLPIRWMPPESILY--------------------------------RKFT-TESDVWSFGVVLWEIFTY--G--------------KQPWYQ--------------------------------------------------LSNTEAIDCITQG--RELERPRACP-----------------------------------------------------------------------------------------------------PEVYAIMRGCWQREPQQRHS--------------IKDVHARLQA
Activation segment
DFGMSRDIYSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRTMLPIRWMPPE
Binding pocket
WELGEGAFGKVFLVAVKALDFQREAELLTMLQQHIVRFFGVLMVFEYMRHGDLNRFLRSYLAGLHFVHRDLATRNCLVIGDFGMS
Ligand info
Orthosteric ligand
7HF
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5H3Q, Chain A