5H2U Chain A
Protein-tyrosine kinase 6 (PTK6)
Inactive — 0.1%DFG-inαC-outType1 · 1N1
Resolution
2.24 Å
R-value
0.208
Predicted activity confidence0.1%
Structure info
Alternate conformationB
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPTFKALRERLSSFTSHHHH
UniProt reference sequence
FTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSS
Aligned reference sequence
FTLC----------------RKLGSGY----------------FGEVFEGLW--K-------------------------------------DRVQVAIKVIS--RDNLLH----------------------------QQMLQSEIQAMKKL--------------------------RHKHILALYAVVSVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVYIITELMAK--------------GSLLELLRD--SDEK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLPVSELLDIAWQVAEGMCYLESQ---------------------------------------------NYIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTLCKVGDFGLARLIKEDVYL--S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HDHNIPYKWTAPEALSR--------------------------------GHYS-TKSDVWSFGILLHEMFSR--G--------------QVPYPG--------------------------------------------------MSNHEAFLRVDAG--YRMPCPLECP-----------------------------------------------------------------------------------------------------PSVHKLMLTCWCRDPEQRPC--------------FKALRERLSS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FTLC----------------RKLGSGY----------------FGEVFEGLW--K-------------------------------------DRVQVAIKVIS--RDNLLH----------------------------QQMLQSEIQAMKKL--------------------------RHKHILALYAVVSVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVYIITELMAK--------------GSLLELLR---SDEK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLPVSELLDIAWQVAEGMCYLESQ---------------------------------------------NYIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTLCKVGDFGLARLIKEDVYL--S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HDHNIPYKWTAPEALSR--------------------------------GHYS-TKSDVWSFGILLHEMFSR--G--------------QVPYPG--------------------------------------------------MSNHEAFLRVDAG--YRMPCPLECP-----------------------------------------------------------------------------------------------------PSVHKLMLTCWCRDPEQRPT--------------FKALRERLSS
Activation segment
DFGLARLIKEDVYL--S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HDHNIPYKWTAPE
Binding pocket
RKLGSGYFGEVFEVAIKVIMLQSEIQAMKKLRKHILALYAVYIITELMAKGSLLELLR_YLESQNYIHRDLAARNILVVGDFGLA
Ligand info
Orthosteric ligand
1N1
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5H2U, Chain A