5GZ9 Chain A
Protein O-mannose kinase (POMK)
Active — 90.3%DFG-outαC-outATPlike,Allosteric · ANP
Resolution
2.4 Å
R-value
0.234
Predicted activity confidence90.3%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
CPPGYFRMGRMRQCSRWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSRLTRLEMKEDFLHGLQMLKSLQSEHVVTLVGYCEEDGTILTEYHPLGSLSNLEETLQKYQDVNTWQHRLQLAMEYVSIINYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDSGVLIKCGHRELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIWKIPDVSSFLLGHVEGSDMVRFHLFDIHKACKSQIPAERPTAQNVLDAYQRVFHSL
UniProt reference sequence
VRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLGYCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGMLVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDISSFLLGHIEGSDMVRFHLFDIHKACKSQTPSERPTAQDVLETYQK
Aligned reference sequence
VRQL----------------KRVGEGA----------------VKRVFLSEW----------------------------------------KEHKVALSQLT--SLEM------------------------------KDDFLHGLQMLKSL--------------------------QGTHVVTLLGYCED----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNTMLTEYHPL--------------GSLSNLEET--LNLSKYQN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNTWQHRLELAMDYVSIINYLHHS--PVG----------------------------------------TRVMCDSNDLPKTLSQYLLTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NFSILANDLDALPLVNHSSGM--LVKC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHRELHGDFVAPEQLWP--YGEDVPFHDDLM------------------PSYD-EKIDIWKIPDISSFLLGH----------------------------------------------------------------------------------------IEGSDMVR-------------------------------------------------------------------------------------------------------FHLFDIHKACKSQTPSERPT--------------AQDVLETYQK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VRQL----------------KRVGEGA----------------VKRVFLSEW----------------------------------------KEHKVALSRLT--RLEM------------------------------KEDFLHGLQMLKSL--------------------------QSEHVVTLVGYCEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGTILTEYHPL--------------GSLSNLEET----LQKYQD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNTWQHRLQLAMEYVSIINYLHHS--PLG----------------------------------------TRVMCDSNDLPKTLSQYLLTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NFSIVANDLDALPLV--DSGV--LIKC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHRELHGDFVAPEQLWP--YGEDTPFQDDLM------------------PSYN-EKVDIWKIPDVSSFLLGH----------------------------------------------------------------------------------------VEGSDMVR-------------------------------------------------------------------------------------------------------FHLFDIHKACKSQIPAERPT--------------AQNVLDAYQL
Activation segment
DLDALPLV--DSGV--LIKC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHRELHGDFVAPE
Binding pocket
LKRVGEGAVKRVFVALSRLFLHGLQMLKSLQSHVVTLVGYCLTEYHPLGSLSNLEETLQYLHHSPLGTRVMCDSNDLPLTSNFSI
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike,Allosteric
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5GZ9, Chain A