5GZ8 Chain A
Protein O-mannose kinase (POMK)
Active — 99.8%DFG-outαC-out
Resolution
2.5 Å
R-value
0.274
Predicted activity confidence99.8%
Structure info
Alternate conformation—
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
CPPGYFRMGRMRQCSRWLSCEELRTEVRQLKRVGKRVFLSEWKEHKVALSRLTRLEMKEDFLHGLQMLKSLQSEHVVTLVGYCEEDGTILTEYHPLGSLSNLEETLQQDVNTWQHRLQLAMEYVSIINYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDVLIKCGHRELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIWKIPDVSSFLLGHVEGSDMVRFHLFDIHKACKSQIPAERPTAQNVLDAYQRVFHSL
UniProt reference sequence
VRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLGYCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGMLVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDISSFLLGHIEGSDMVRFHLFDIHKACKSQTPSERPTAQDVLETYQK
Aligned reference sequence
VRQL----------------KRVGEGA----------------VKRVFLSEW----------------------------------------KEHKVALSQLT--SLEM------------------------------KDDFLHGLQMLKSL--------------------------QGTHVVTLLGYCED----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNTMLTEYHPL--------------GSLSNLEET--LNLSKYQN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNTWQHRLELAMDYVSIINYLHHS--PVG----------------------------------------TRVMCDSNDLPKTLSQYLLTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NFSILANDLDALPLVNHSSGM--LVKC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHRELHGDFVAPEQLWP--YGEDVPFHDDLM------------------PSYD-EKIDIWKIPDISSFLLGH----------------------------------------------------------------------------------------IEGSDMVR-------------------------------------------------------------------------------------------------------FHLFDIHKACKSQTPSERPT--------------AQDVLETYQK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VRQL----------------KRVG--------------------KRVFLSEW----------------------------------------KEHKVALSRLT--RLEM------------------------------KEDFLHGLQMLKSL--------------------------QSEHVVTLVGYCEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGTILTEYHPL--------------GSLSNLEET--L----QQD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNTWQHRLQLAMEYVSIINYLHHS--PLG----------------------------------------TRVMCDSNDLPKTLSQYLLTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NFSIVANDLDALPLV----DV--LIKC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHRELHGDFVAPEQLWP--YGEDTPFQDDLM------------------PSYN-EKVDIWKIPDVSSFLLGH----------------------------------------------------------------------------------------VEGSDMVR-------------------------------------------------------------------------------------------------------FHLFDIHKACKSQIPAERPT--------------AQNVLDAYQL
Activation segment
DLDALPLV----DV--LIKC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHRELHGDFVAPE
Binding pocket
MRQCSRWLSCEELRVGKRVKVALSRLTRLEMKDFLHGLQMLHVVTLVGY_EEDGTILTERLQLAMEYVSIINYLHHSPDSNDLPK
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5GZ8, Chain A