5G6V Chain A
Cyclin-dependent kinase 16 (CDK16)
Inactive — 0.0%DFG-outαC-inType2 · 919
Resolution
2.2 Å
R-value
0.211
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms11
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKTYDNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEA
UniProt reference sequence
YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF
Aligned reference sequence
YIKL----------------DKLGEGT----------------YATVYKGKS--KL------------------------------------TDNLVALKEIR--LEHEEGA---------------------------PCTAIREVSLLKDL--------------------------KHANIVTLHDIIHTEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTLVFEYLD---------------KDLKQYLDD--CGN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IINMHNVKLFLFQLLRGLAYCHRQ---------------------------------------------KVLHRDL-----KPQNLLINE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGELKLADFGLARAKSIPTKT--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNEVVTLWYRPPDILLG--S-----------------------------TDYS-TQIDMWGVGCIFYEMATG-----------------RPLFPG--------------------------------------------------STVEEQLHFIFRI--LGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLD------------------------------------------------------------------------SDGADLLTKLLQFEGRNRIS--------------AEDAMKHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YIKL----------------DKLGEGT----------------YATVYKGKS--KL------------------------------------TDNLVALKEIR--LEHEEGA---------------------------PCTAIREVSLLKDL--------------------------KHANIVTLHDIIHTEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTLVFEYLD---------------KDLKQYLDD--CGN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IINMHNVKLFLFQLLRGLAYCHRQ---------------------------------------------KVLHRDL-----KPQNLLINE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGELKLADFGLARA-----KT--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNEVVTLWYRPPDILLG--S-----------------------------TDYS-TQIDMWGVGCIFYEMATG-----------------RPLFPG--------------------------------------------------STVEEQLHFIFRI--LGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLD------------------------------------------------------------------------SDGADLLTKLLQFEGRNRIS--------------AEDAMKHPFF
Activation segment
DFGLARA-----KT--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNEVVTLWYRPPD
Binding pocket
DKLGEGTYATVYKVALKEITAIREVSLLKDLKANIVTLHDITLVFEYLD_KDLKQYLDDYCHRQKVLHRDLKPQNLLILADFGLA
Ligand info
Orthosteric ligand
919
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5G6V, Chain A