5FQD Chain F
Casein kinase I isoform alpha (CSNK1A1)
Active — 100.0%DFG-inαC-in
Resolution
2.45 Å
R-value
0.182
Predicted activity confidence100.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQ
UniProt reference sequence
YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRI
Aligned reference sequence
YKLV----------------RKIGSGS----------------FGDIYLAIN--IT------------------------------------NGEEVAVKLES--QKAR------------------------------HPQLLYESKLYKIL--Q-----------------------GGVGIPHIRWYGQEKD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVLVMDLLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTMKTVLMLADQMISRIEYVHTK---------------------------------------------NFIHRDI-----KPDNFLMGI--GRH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CNKLFLIDFGLAKKYRDNRTR--QHIPYRED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASINAHLG--------------------------------IEQS-RRDDMESLGYVLMYFNRT-----------------SLPWQG--LKAATKK-----------------------------------------QKYEKISEKKMST--PVEVLCKGFP-----------------------------------------------------------------------------------------------------AEFAMYLNYCRGLRFEEAPD--------------YMYLRQLFRI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YKLV----------------RKIGSGS----------------FGDIYLAIN--IT------------------------------------NGEEVAVKLES--QKAR------------------------------HPQLLYESKLYKIL--Q-----------------------GGVGIPHIRWYGQEKD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNVLVMDLLG---------------PSLEDLFNF--CSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTMKTVLMLADQMISRIEYVHTK---------------------------------------------NFIHRDI-----KPDNFLMGI--GRH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CNKLFLIDFGLAKKYRDNRTR--QHIPYRED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASINAHLG--------------------------------IEQS-RRDDMESLGYVLMYFNRT-----------------SLPWQG--LKAATKK-----------------------------------------QKYEKISEKKMST--PVEVLCKGFP-----------------------------------------------------------------------------------------------------AEFAMYLNYCRGLRFEEAPD--------------YMYLRQLFRI
Activation segment
DFGLAKKYRDNRTR--QHIPYRED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNLTGTARYASIN
Binding pocket
RKIGSGSFGDIYLVAVKLEQLLYESKLYKILQVGIPHIRWYVLVMDLLG_PSLEDLFNFYVHTKNFIHRDIKPDNFLMLIDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5FQD, Chain F