5FLF Chain E
Fibroblast growth factor receptor 1 (FGFR1)
Inactive — 0.1%DFG-inαC-in
Resolution
2.58 Å
R-value
0.197
Predicted activity confidence0.1%
Structure info
Alternate conformationB
Missing atoms0
Missing residues5
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PEDPRWELPRDRLVLGKPLGQVVLAEAIGLDKDKPNRVTKVAVKMLKATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARREQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAGRLPVKWMAPEALFDGIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT
UniProt reference sequence
LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
Aligned reference sequence
LVLG----------------KPLGEGC----------------FGQVVLAEA--IGLDKDKPN-----------------------------RVTKVAVKMLK--SDATEKD---------------------------LSDLISEMEMMKMI--G-----------------------KHKNIINLLGACTQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVEYASK--------------GNLREYLQA--RRPPGLEYCYNPSHNPEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLSSKDLVSCAYQVARGMEYLASK---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLARDIHHIDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPEALFD--------------------------------RIYT-HQSDVWSFGVLLWEIFTL--G--------------GSPYPG--------------------------------------------------VPVEELFKLLKEG--HRMDKPSNCT-----------------------------------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT--------------FKQLVEDLDR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------KPL---------------------GQVVLAEA--IGLDKDKPN-----------------------------RVTKVAVKMLK----ATEKD---------------------------LSDLISEMEMMKMI--G-----------------------KHKNIINLLGACTQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVEYASK--------------GNLREYLQA--RR---------------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLSSKDLVSCAYQVARGMEYLASK---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRLPVKWMAPEALFD--------------------------------GIYT-HQSDVWSFGVLLWEIFTL--G--------------GSPYPG--------------------------------------------------VP--ELFKLLKEG--HRMDKPSNCT-----------------------------------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT--------------FKQLVEDLDR
Activation segment
DFGLA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRLPVKWMAPE
Binding pocket
KPLG_____QVVLVAVKMLDLISEMEMMKMIGKNIINLLGAYVIVEYASKGNLREYLQAYLASKKCIHRDLAARNVLVIADFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5FLF, Chain E