5ES1 Chain A
MAP/microtubule affinity-regulating kinase 4 (MARK4)
Inactive — 0.8%DFG-inαC-inType1 · 5RC
Resolution
2.8 Å
R-value
0.243
Predicted activity confidence0.8%
Structure info
Alternate conformation—
Missing atoms49
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRK
UniProt reference sequence
YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI
Aligned reference sequence
YRLL----------------RTIGKGN----------------FAKVKLARH--IL------------------------------------TGREVAIKIID--KTQLNPSS--------------------------LQKLFREVRIMKGL--------------------------NHPNIVKLFEVIETEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLYLVMEYASA--------------GEVFDYLVS--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVHYCHQK---------------------------------------------NIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EANIKIADFGFSNEFTLGSKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTFCGSPPYAAPELFQG--------------------------------KKYDGPEVDIWSLGVILYTLVSG-----------------SLPFDG--------------------------------------------------HNLKELRERVLRG--KYRVPFYMS------------------------------------------------------------------------------------------------------TDCESILRRFLVLNPAKRCT--------------LEQIMKDKWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YRLL----------------RTIGKGN----------------FAKVKLARH--IL------------------------------------TGREVAIKIID--KTQLNPSS--------------------------LQKLFREVRIMKGL--------------------------NHPNIVKLFEVIETEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLYLVMEYASA--------------GEVFDYLVS--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVHYCHQK---------------------------------------------NIVHRDL-----KAENLLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EANIKIADFGFSN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPPYAAPELFQG--------------------------------KKYDGPEVDIWSLGVILYTLVSG-----------------SLPFDG--------------------------------------------------HNLKELRERVLRG--KYRVPFYMS------------------------------------------------------------------------------------------------------TDCESILRRFLVLNPAKRCT--------------LEQIMKDKWI
Activation segment
DFGFSN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPPYAAPE
Binding pocket
RTIGKGNFAKVKLVAIKIIKLFREVRIMKGLNPNIVKLFEVYLVMEYASAGEVFDYLVSYCHQKNIVHRDLKAENLLLIADFGFS
Ligand info
Orthosteric ligand
5RC
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5ES1, Chain A