5EFQ Chain C
Cyclin-dependent kinase 13 (CDK13)
Active — 100.0%DFG-inαC-inATPlike · ADP
Resolution
2.0 Å
R-value
0.197
Predicted activity confidence100.0%
Structure info
Alternate conformation—
Missing atoms10
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
WGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQM
UniProt reference sequence
FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFL
Aligned reference sequence
FDII----------------GIIGEGT----------------YGQVYKARD--KD------------------------------------TGEMVALKKVR--LDNEKEGF--------------------------PITAIREIKILRQL--------------------------THQSIINMKEIVTDKE--DALDFKKDKG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFYLVFEYMD---------------HDLMGLLES--GLV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFNENHIKSFMRQLMEGLDYCHKK---------------------------------------------NFLHRDI-----KCSNILLNN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGQIKLADFGLARLYSSEESR--PY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNKVITLWYRPPELLLG--E-----------------------------ERYT-PAIDVWSCGCILGELFTK-----------------KPIFQA--------------------------------------------------NQELAQLELISRI--CGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIP------------------------------------------------------------------------AAALDLFDYMLALDPSKRCT--------------AEQALQCEFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FDII----------------GIIGEGT----------------YGQVYKARD--KD------------------------------------TGEMVALKKVR--LDNEKEGF--------------------------PITAIREIKILRQL--------------------------THQSIINMKEIVTDKE-----------G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFYLVFEYMD---------------HDLMGLLES--GLV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFNENHIKSFMRQLMEGLDYCHKK---------------------------------------------NFLHRDI-----KCSNILLNN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGQIKLADFGLARLYSSEESR--PY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKVITLWYRPPELLLG--E-----------------------------ERYT-PAIDVWSCGCILGELFTK-----------------KPIFQA--------------------------------------------------NQELAQLELISRI--CGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIP------------------------------------------------------------------------AAALDLFDYMLALDPSKRCT--------------AEQALQCEFL
Activation segment
DFGLARLYSSEESR--PY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKVITLWYRPPE
Binding pocket
GIIGEGTYGQVYKVALKKVTAIREIKILRQLTQSIINMKEIYLVFEYMD_HDLMGLLESYCHKKNFLHRDIKCSNILLLADFGLA
Ligand info
Orthosteric ligand
ADP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5EFQ, Chain C