5E91 Chain A
TGF-beta receptor type-2 (TGFBR2)
Inactive — 29.1%DFG-inαC-inType1 · 5L4
Resolution
2.42 Å
R-value
0.209
Predicted activity confidence29.1%
Structure info
Alternate conformation—
Missing atoms12
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ELLPIELDTLVGKGRFAEVYKAKLKETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEH
UniProt reference sequence
IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE
Aligned reference sequence
IELD----------------TLVGKGR----------------FAEVYKAKL--KQNTSE--------------------------------QFETVAVKIFP--YEE-------------------------------YASWKTEKDIFSDI--NL----------------------KHENILQFLTAEERKT--ELGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QYWLITAFHAK--------------GNLQEYLTR--H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VISWEDLRKLGSSLARGIAHLHSD--HTPCGRPKM----------------------------------PIVHRDL-----KSSNILVKN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTCCLCDFGLSLRLDPTLSV--DDLAN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQVGTARYMAPEVLES--RMNLEN------------------------VESF-KQTDVYSMALVLWEMTSR--CNAVGEVKDY-----EPPFGS--KVREH-------------------------------------------PCVESMKDNVLRD--RGRPEIPSFWLNHQGI-----------------------------------------------------------------------------------------------QMVCETLTECWDHDPEARLT--------------AQCVAERFSE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IELD----------------TLVGKGR----------------FAEVYKAKL--K---------------------------------------ETVAVKIFP--YEE-------------------------------YASWKTEKDIFSDI--NL----------------------KHENILQFLTAEERKT--ELGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QYWLITAFHAK--------------GNLQEYLTR--H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VISWEDLRKLGSSLARGIAHLHSD--HTPCGRPKM----------------------------------PIVHRDL-----KSSNILVKN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTCCLCDFGLSLRLDPTLSV--DDLAN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQVGTARYMAPEVLAS--AMNLEN------------------------VESF-KQTDVYSMALVLWEMTSR--CNAVGEVKDY-----EPPFGS--KVREH-------------------------------------------PCVASMADNVLAD--AGRPEIPSFWLNHQGI-----------------------------------------------------------------------------------------------QMVCETLTECWDHDPEARLT--------------AQCVAERFSE
Activation segment
DFGLSLRLDPTLSV--DDLAN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQVGTARYMAPE
Binding pocket
TLVGKGRFAEVYKVAVKIFSWKTEKDIFSDINENILQFLTAWLITAFHAKGNLQEYLTRGRPKMPIVHRDLKSSNILVLCDFGLS
Ligand info
Orthosteric ligand
5L4
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5E91, Chain A