5E8V Chain A
TGF-beta receptor type-2 (TGFBR2)
Active — 87.2%DFG-inαC-in
Resolution
1.69 Å
R-value
0.194
Predicted activity confidence87.2%
Structure info
Alternate conformationB
Missing atoms12
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ELLPIELDTLVGKGRFAEVYKAKLKFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL
UniProt reference sequence
IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE
Aligned reference sequence
IELD----------------TLVGKGR----------------FAEVYKAKL--KQNTSE--------------------------------QFETVAVKIFP--YEE-------------------------------YASWKTEKDIFSDI--NL----------------------KHENILQFLTAEERKT--ELGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QYWLITAFHAK--------------GNLQEYLTR--H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VISWEDLRKLGSSLARGIAHLHSD--HTPCGRPKM----------------------------------PIVHRDL-----KSSNILVKN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTCCLCDFGLSLRLDPTLSV--DDLAN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQVGTARYMAPEVLES--RMNLEN------------------------VESF-KQTDVYSMALVLWEMTSR--CNAVGEVKDY-----EPPFGS--KVREH-------------------------------------------PCVESMKDNVLRD--RGRPEIPSFWLNHQGI-----------------------------------------------------------------------------------------------QMVCETLTECWDHDPEARLT--------------AQCVAERFSE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IELD----------------TLVGKGR----------------FAEVYKAKL--K--------------------------------------FETVAVKIFP--YEE-------------------------------YASWKTEKDIFSDI--NL----------------------KHENILQFLTAEERKT--ELGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QYWLITAFHAK--------------GNLQEYLTR--H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VISWEDLRKLGSSLARGIAHLHSD--HTPCGRPKM----------------------------------PIVHRDL-----KSSNILVKN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTCCLCDFGLSLRLDPTLSV--DDLAN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQVGTARYMAPEVLAS--AMNLEN------------------------VESF-KQTDVYSMALVLWEMTSR--CNAVGEVKDY-----EPPFGS--KVREH-------------------------------------------PCVASMADNVLAD--AGRPEIPSFWLNHQGI-----------------------------------------------------------------------------------------------QMVCETLTECWDHDPEARLT--------------AQCVAERFSE
Activation segment
DFGLSLRLDPTLSV--DDLAN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQVGTARYMAPE
Binding pocket
TLVGKGRFAEVYKVAVKIFSWKTEKDIFSDINENILQFLTAWLITAFHAKGNLQEYLTRGRPKMPIVHRDLKSSNILVLCDFGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5E8V, Chain A