5DFP Chain A
Serine/threonine-protein kinase PAK 1 (PAK1)
Active — 99.6%DFG-inαC-inType1.5_Front · 59U
Resolution
2.2 Å
R-value
0.193
Predicted activity confidence99.6%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT
UniProt reference sequence
YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL
Aligned reference sequence
YTRF----------------EKIGQGA----------------SGTVYTAMD--VA------------------------------------TGQEVAIKQMN--LQQQPK----------------------------KELIINEILVMREN--------------------------KNPNIVNYLDSYLVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEYLAG--------------GSLTDVVTE--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALEFLHSN---------------------------------------------QVIHRDI-----KSDNILLGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSVKLTDFGFCAQITPEQSK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STMVGTPYWMAPEVVTR--------------------------------KAYG-PKVDIWSLGIMAIEMIEG-----------------EPPYLN--------------------------------------------------ENPLRALYLIATN--GTPELQNPEKLS---------------------------------------------------------------------------------------------------AIFRDFLNRCLEMDVEKRGS--------------AKELLQHQFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YTRF----------------EKIGQGA----------------SGTVYTAMD--VA------------------------------------TGQEVAIRQMN--LQQQPK----------------------------KELIINEILVMREN--------------------------KNPNIVNYLDSYLVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEYLAG--------------GSLTDVVTE--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALEFLHSN---------------------------------------------QVIHRDI-----KSDNILLGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSVKLTDFGFCAQITPEQSK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-MVGTPYWMAPEVVTR--------------------------------KAYG-PKVDIWSLGIMAIEMIEG-----------------EPPYLN--------------------------------------------------ENPLRALYLIATN--GTPELQNPEKLS---------------------------------------------------------------------------------------------------AIFRDFLNRCLEMDVEKRGS--------------AKELLQHQFL
Activation segment
DFGFCAQITPEQSK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-MVGTPYWMAPE
Binding pocket
EKIGQGASGTVYTVAIRQMLIINEILVMRENKPNIVNYLDSWVVMEYLAGGSLTDVVTEFLHSNQVIHRDIKSDNILLLTDFGFC
Ligand info
Orthosteric ligand
59U
Allosteric ligand
None
Ligand typeType1.5_Front
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5DFP, Chain A