5D7V Chain D
Protein-tyrosine kinase 6 (PTK6)
Inactive — 0.0%DFG-inαC-out
Resolution
2.33 Å
R-value
0.222
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPTFKALRERLSSFTSHH
UniProt reference sequence
FTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSS
Aligned reference sequence
FTLC----------------RKLGSGY----------------FGEVFEGLW--K-------------------------------------DRVQVAIKVIS--RDNLLH----------------------------QQMLQSEIQAMKKL--------------------------RHKHILALYAVVSVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVYIITELMAK--------------GSLLELLRD--SDEK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLPVSELLDIAWQVAEGMCYLESQ---------------------------------------------NYIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTLCKVGDFGLARLIKEDVYL--S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HDHNIPYKWTAPEALSR--------------------------------GHYS-TKSDVWSFGILLHEMFSR--G--------------QVPYPG--------------------------------------------------MSNHEAFLRVDAG--YRMPCPLECP-----------------------------------------------------------------------------------------------------PSVHKLMLTCWCRDPEQRPC--------------FKALRERLSS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FTLC----------------RKLGSGY----------------FGEVFEGLW--K-------------------------------------DRVQVAIKVIS--RDNLLH----------------------------QQMLQSEIQAMKKL--------------------------RHKHILALYAVVSVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVYIITELMAK--------------GSLLELLRD--SDEK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLPVSELLDIAWQVAEGMCYLESQ---------------------------------------------NYIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTLCKVGDFGLARLIKEDVYL--S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HDHNIPYKWTAPEALSR--------------------------------GHYS-TKSDVWSFGILLHEMFSR--G--------------QVPYPG--------------------------------------------------MSNHEAFLRVDAG--YRMPCPLECP-----------------------------------------------------------------------------------------------------PSVHKLMLTCWCRDPEQRPT--------------FKALRERLSS
Activation segment
DFGLARLIKEDVYL--S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HDHNIPYKWTAPE
Binding pocket
RKLGSGYFGEVFEVAIKVIMLQSEIQAMKKLRKHILALYAVYIITELMAKGSLLELLRDYLESQNYIHRDLAARNILVVGDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5D7V, Chain D