5CU3 Chain B
Casein kinase II subunit alpha (CSNK2A1)
Active — 100.0%DFG-inαC-inType1 · 54S
Resolution
1.79 Å
R-value
0.184
Predicted activity confidence100.0%
Structure info
Alternate conformationB
Missing atoms1
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV
UniProt reference sequence
YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF
Aligned reference sequence
YQLV----------------RKLGRGK----------------YSEVFEAIN--IT------------------------------------NNEKVVVKILK--PVK-------------------------------KKKIKREIKILENL--R-----------------------GGPNIITLADIVKDPV--SR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPALVFEHVNN--------------TDFKQLYQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLTDYDIRFYMYEILKALDYCHSM---------------------------------------------GIMHRDV-----KPHNVMIDH--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HRKLRLIDWGLAEFYHPGQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPELLVD--Y-----------------------------QMYD-YSLDMWSLGCMLASMIFR--K--------------EPFFHG--------------------------------------------------HDNYDQLVRIAKV--LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVS-----------------------------------------------------------------PEALDFLDKLLRYDHQSRLT--------------AREAMEHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQLV----------------RKLGRGK----------------YSEVFEAIN--IT------------------------------------NNEKVVVKILK--PVK-------------------------------KKKIKREIKILENL--R-----------------------GGPNIITLADIVKDPV--SR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPALVFEHVNN--------------TDFKQLYQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLTDYDIRFYMYEILKALDYCHSM---------------------------------------------GIMHRDV-----KPHNVMIDH--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HRKLRLIDWGLAEFYHPGQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPELLVD--Y-----------------------------QMYD-YSLDMWSLGCMLASMIFR--K--------------EPFFHG--------------------------------------------------HDNYDQLVRIAKV--LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVS-----------------------------------------------------------------PEALDFLDKLLRYDHQSRLT--------------AREAMEHPYF
Activation segment
DWGLAEFYHPGQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPE
Binding pocket
RKLGRGKYSEVFEVVVKILKIKREIKILENLRPNIITLADIALVFEHVN_NTDFKQ__LYCHSMGIMHRDVKPHNVMILIDWGLA
Ligand info
Orthosteric ligand
54S
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5CU3, Chain B